Exercise in Breast Cancer Survivors
| Status: | Completed |
|---|---|
| Conditions: | Breast Cancer, Cancer, Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology, Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 2/7/2015 |
| Start Date: | April 2012 |
| End Date: | April 2013 |
| Contact: | Natale Sheehan, MD |
| Email: | ntsheehan@umc.edu |
| Phone: | 601-984-5590 |
Exercise in Breast Cancer Survivors: Analysis of Angiogenic Profile
The investigators hypothesize that exercise in postmenopausal breast cancer survivors will
result in an increase in the plasma concentrations of angiostatic factors and a decrease in
the plasma concentrations of angiogenic factors. Exercise is expected to result in a
circulating angiostatic phenotype that inhibits adipose tissue mass, growth of breast cancer
tumor, growth of microscopic residual disease after breast cancer resection, decreases rates
of local-regional recurrence, decreases rates of distant recurrence, and increases survival.
result in an increase in the plasma concentrations of angiostatic factors and a decrease in
the plasma concentrations of angiogenic factors. Exercise is expected to result in a
circulating angiostatic phenotype that inhibits adipose tissue mass, growth of breast cancer
tumor, growth of microscopic residual disease after breast cancer resection, decreases rates
of local-regional recurrence, decreases rates of distant recurrence, and increases survival.
Inclusion Criteria:
- > 18 years of age and < 65 years of age
- Female
- BMI > 25
- Weight < 350 pounds
- English as a primary language
- Postmenopausal
- Invasive ER-positive cancer on biopsy and subsequent definitive surgical therapy
- Received and Completed standard of care adjuvant therapy (Concurrent endocrine
therapy acceptable)
- 6-12 months after completion of therapy (excluding adjuvant endocrine therapy) at
time of randomization
Exclusion Criteria:
- Recurrent breast cancer
- DCIS only (no invasive component)
- Taking a Beta Blocker or Verapamil
- Pregnant
- Wheelchair bound
- Unable to ambulate independently
- Concurrent uncontrolled medical or psychiatric disorder
- Open wound
- Stage IV breast cancer
- Progression of disease
- Bilateral mastectomies
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