The Effect of OMT on Patients With COPD: Correlating Pulmonary Function Tests With Biochemical Alterations
| Status: | Completed |
|---|---|
| Conditions: | Chronic Obstructive Pulmonary Disease, Pulmonary |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 49 - 80 |
| Updated: | 4/21/2016 |
| Start Date: | April 2013 |
| End Date: | August 2015 |
The Effect of Osteopathic Manipulative Treatment on Patients With Chronic Obstructive Pulmonary Disease:Correlating Pulmonary Function Tests With Biochemical Alterations
This project proposes to test the hypothesis that osteopathic manipulative treatment (OMT)
given to patients with moderate to severe chronic obstructive pulmonary disease (COPD)
enrolled in a 12-week pulmonary rehabilitation program (PRP) will result in improved
respiratory pump function over and above that seen in sham and control groups. Specifically,
we will study the effects of three OMT techniques: (a) thoracic inlet indirect myofascial
release; (b) rib raising with continued stretch of the paraspinal muscle to the L2 level;
and (c) cervical paraspinal muscle stretch with suboccipital muscle release. The key
clinical readouts will include: spirometry, P100 (and index of diaphragm and inspiratory
muscle efficiency), maximum inspiratory pressure (MIP) and maximum expiratory pressure
(MEP), as well as laser evaluation of chest wall excursion. Supplementing these objective
parameters will be several more subjective clinical outcome measures: exercise tolerance
(6-minute walk test), dyspnea (shortness of breath questionnaire), and quality of life
questionnaire. Finally, an attempt will be made to correlate biochemical alterations that
may shed light on the biological mechanism underlying the OMT procedures.
given to patients with moderate to severe chronic obstructive pulmonary disease (COPD)
enrolled in a 12-week pulmonary rehabilitation program (PRP) will result in improved
respiratory pump function over and above that seen in sham and control groups. Specifically,
we will study the effects of three OMT techniques: (a) thoracic inlet indirect myofascial
release; (b) rib raising with continued stretch of the paraspinal muscle to the L2 level;
and (c) cervical paraspinal muscle stretch with suboccipital muscle release. The key
clinical readouts will include: spirometry, P100 (and index of diaphragm and inspiratory
muscle efficiency), maximum inspiratory pressure (MIP) and maximum expiratory pressure
(MEP), as well as laser evaluation of chest wall excursion. Supplementing these objective
parameters will be several more subjective clinical outcome measures: exercise tolerance
(6-minute walk test), dyspnea (shortness of breath questionnaire), and quality of life
questionnaire. Finally, an attempt will be made to correlate biochemical alterations that
may shed light on the biological mechanism underlying the OMT procedures.
According to the above directions (provide a more extensice description, if desired), I am
choosing to just submit the brief summary.
Thank you, Sherman Gorbis, DO
choosing to just submit the brief summary.
Thank you, Sherman Gorbis, DO
Inclusion Criteria:
- postbronchodilator FEV1/FVC <0.7 and FEV1 <80% predicted [FEV1 =volume that has been
exhaled at the end of the first second of forced expiration] and FVC volume of air
that can be forcibly blown out after full inspiration]
- history of smoking >20 pack-years
- stable condition at inclusion with no infection or exacerbation for at least two
months
- optimal medical therapy for at least eight weeks with no change
Exclusion Criteria:
- history of active pulmonary disease such as asthma
- positive bronchodilator test
- treatment with N-acetylcysteine
- previous diagnosis of hypertension or current anti-hypertensive treatment
- known unstable or moderate to severe heart disease (arrhythmia, ischemic heart
disease, or cardiomyopathy)
- previous diagnosis of chronic illness such as diabetes, renal failure,
hypercholesterolemia, hepatic cirrhosis, cancer, rheumatoid arthritis or any other
systemic inflammatory disease
- neuromuscular or disabling cognitive problems
- engagement in any exercise-training program during the past three months
- substance abuse in the preceding six months
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