OCT-guided DSAEK Graft Shaping and Smoothing
| Status: | Completed |
|---|---|
| Conditions: | Ocular |
| Therapuetic Areas: | Ophthalmology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 3/30/2013 |
| Start Date: | January 2012 |
| End Date: | December 2015 |
| Contact: | David Davis-Boozer |
| Email: | DDBoozer@deverseye.org |
| Phone: | 503-413-8377 |
Randomized Clinical Trial of OCT-guided DSAEK Graft Shaping and Smoothing
The primary goal of this study is to determine if excimer laser smoothing of the cornea
before Descemet's stripping automated endothelial keratoplasty (DSAEK)improves postoperative
Best Spectacle Corrected Visual Acuity (BSCVA).
Many surgeons are moving away from full thickness corneal transplantation (because of risks
involving rejection, irregular astigmatism, and wound dehiscence) to partial thickness
transplantations of either the anterior or posterior (endothelial) layers. However this
technique is not without its drawbacks. DSAEK uses a mechanical microkeratome to cut the
graft, but vision is limited by the roughness of the cut surface.
DSAEK can lead to significant refractive error due to the non-uniform shape of the
microkeratome cut graft, and the roughness of the microkeratome cut surface limits vision to
an average of 20/31. Optical coherence tomography (OCT)-guided laser shaping and smoothing
may improve the refractive and visual outcome.
Inclusion Criteria:
- Adults with visual complaint and objective evidence of decreased vision due to
corneal edema related to Fuchs' corneal endothelial dystrophy
Exclusion Criteria:
- Inability to give informed consent
- Inability to maintain stable fixation for OCT imaging
- Inability to commit to required visits to complete the study
- Eyes with concurrent cataract, retinal diseases, glaucoma, or other eye conditions
that may limit the visual outcome after surgery
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