Lateral Canthal Rhytides With Medium Depth Chemical Peel With or Without Pretreatment With Botulinum Toxin A
| Status: | Completed |
|---|---|
| Conditions: | Cosmetic |
| Therapuetic Areas: | Dermatology / Plastic Surgery |
| Healthy: | No |
| Age Range: | 30 - 75 |
| Updated: | 4/2/2016 |
| Start Date: | September 2011 |
| End Date: | September 2013 |
| Contact: | Rebecca Tung, MD |
| Email: | rtung@lumc.edu |
| Phone: | 708-216-8000 |
Treatment of Lateral Canthal Rhytides With Medium Depth Chemical Peel With or Without Pretreatment With Botulinum Toxin A: A Split-face, Rater-blinded Randomized Control Trial
This study is being done to find out if the use of botulinum toxin prior to a medium
strength combination chemical peel (Jessner's peel followed by 35% Trichloroacetic acid
peel) will improve the appearance of crow's feet wrinkles when compared to a chemical peel
alone. Botulinum toxin type A is a purified substance, derived from a bacteria that block
muscular nerve signals. Jessner's Peel, a combination of resorcinol (14g), salicylic acid
(14g), and lactic acid (85%) in ethanol (95%), is a superficial chemical peel. These two
products/procedures have been FDA approved to improve the appearance of facial wrinkles.
strength combination chemical peel (Jessner's peel followed by 35% Trichloroacetic acid
peel) will improve the appearance of crow's feet wrinkles when compared to a chemical peel
alone. Botulinum toxin type A is a purified substance, derived from a bacteria that block
muscular nerve signals. Jessner's Peel, a combination of resorcinol (14g), salicylic acid
(14g), and lactic acid (85%) in ethanol (95%), is a superficial chemical peel. These two
products/procedures have been FDA approved to improve the appearance of facial wrinkles.
Wrinkling in the skin is caused by habitual facial expressions, aging, sun damage, smoking,
poor hydration, and various other factors. There are two major types of wrinkles—dynamic and
static. Dynamic wrinkles, which are due to excessive muscle activity, usually of the face,
tend to disappear when you relax your facial muscles. The most common of these dynamic
wrinkles are frown lines, forehead wrinkles, and eye wrinkles (or crow's feet). However, if
the excessive muscle activity is carried on for too long, these do not disappear completely
on relaxation, and are thus called static wrinkles. Static wrinkles are formed either by
chronic excessive muscle activity or are due to the effects of age and gravity, with a loss
of subcutaneous fat. Examples of static wrinkles are the nasolabial folds, which are the
deep grooves running from the sides of the nose to the corners of the mouth.
poor hydration, and various other factors. There are two major types of wrinkles—dynamic and
static. Dynamic wrinkles, which are due to excessive muscle activity, usually of the face,
tend to disappear when you relax your facial muscles. The most common of these dynamic
wrinkles are frown lines, forehead wrinkles, and eye wrinkles (or crow's feet). However, if
the excessive muscle activity is carried on for too long, these do not disappear completely
on relaxation, and are thus called static wrinkles. Static wrinkles are formed either by
chronic excessive muscle activity or are due to the effects of age and gravity, with a loss
of subcutaneous fat. Examples of static wrinkles are the nasolabial folds, which are the
deep grooves running from the sides of the nose to the corners of the mouth.
Inclusion Criteria:
- Age 30 to 75 years old
- In good health
- Has static and dynamic lateral canthal wrinkles ("crow's feet")
- Has the willingness and the ability to understand and provide informed consent and
communicate with the investigator
Exclusion Criteria:
- Pregnant or lactating
- Has received the following treatments:
- botulinum toxin injections in the past 6 months
- ablative laser procedure in the past 6 months
- radiofrequency device treatment in the past 6 months
- ultrasound device treatment in the past 6 months
- medium to deep chemical peel in the past 6 months
- temporary soft tissue augmentation material in the past year
- semi-permanent soft tissue augmentation material in the past 2 years
- permanent soft tissue augmentation material
- Is planning to receive within the next 3 months, any cosmetic procedure (such as any
chemical peels, botulinum toxin injections, ablative or non-ablative laser
procedures, filler injections, radiofrequency procedures, dermabrasion, ultrasound
and face lifting procedures)
- Has an active infection on their face (excluding mild acne
- Has a history of neuromuscular disorders
- Has an allergy to albumin
- Has an allergy to Aquaphor AND petroleum jelly
- Has a history of bleeding disorders
- Is unable to understand the protocol or to give informed consent
- Has a mental illness
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