High Dose Vitamin C in the Critically Ill Patient
| Status: | Recruiting |
|---|---|
| Conditions: | Hospital |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 2/7/2015 |
| Start Date: | February 2013 |
| End Date: | March 2018 |
| Contact: | Susette Coyle, RN |
| Email: | coylesu@rwjms.rutgers.edu |
| Phone: | 732-235-8143 |
The Efficacy of High Dose Vitamin C in the Critically Ill Patient Population
It has been shown that the stress that occurs during trauma, infection and/or shock depletes
many of the body's resources such as Vitamin C (ascorbic acid) which may contribute to
further complications. The purpose of this study is to determine the effectiveness of high
doses of Vitamin C in critically ill patients.
many of the body's resources such as Vitamin C (ascorbic acid) which may contribute to
further complications. The purpose of this study is to determine the effectiveness of high
doses of Vitamin C in critically ill patients.
Inclusion Criteria:
- Activation of the Mass Transfusion Protocol following surgery or trauma.
- Diagnosis of septic shock. Septic shock will be defined as sepsis induced hypotension
(i.e. systolic blood pressure <90mmHg or drop of systolic blood pressure >40mmHg in
the presence of infection) that does not respond to a 2 liter fluid bolus.
Exclusion Criteria:
- Age less than 18 years.
- Pregnant women.
- Creatinine of greater than 2.2 g/dl at time of enrollment, history of chronic kidney
or end stage renal disease, rise in creatinine > 1 g/dl within 24 hours prior to
enrollment.
- Brain death diagnosed within 4 hours of presentation to the trauma bay or intensive
care unit
- Patients with history of hemolytic blood disease, e.g. glucose-6-phosphate
dehydrogenase deficiency, Sickle Cell Disease and Thalassemia.
- Patients in isolated cardiogenic shock.
- History of liver cirrhosis
- Transplant patients (liver, kidney, heart)
We found this trial at
1
site
Click here to add this to my saved trials
