Identification of Molecular Biomarkers to Stratify Patients With Refractory Asthma
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Asthma |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | January 2012 |
| End Date: | June 2016 |
The purpose of this study is to learn more about asthma in people who are not
well-controlled with current asthma medication (refractory asthma). The investigators will
compare data from refractory asthmatic patients here at National Jewish Health to mild
asthmatics subjects and to people without asthma. Study experiments involve looking at
samples from all 3 groups and comparing them at a molecular level. These laboratory
experiments may help identify subtypes of refractory asthmatics that require different
treatments.
well-controlled with current asthma medication (refractory asthma). The investigators will
compare data from refractory asthmatic patients here at National Jewish Health to mild
asthmatics subjects and to people without asthma. Study experiments involve looking at
samples from all 3 groups and comparing them at a molecular level. These laboratory
experiments may help identify subtypes of refractory asthmatics that require different
treatments.
Inclusion Criteria:
- Able to receive Informed Consent
- At least 18 years of age
- ICS < 880 mcg (FP equivalents)
- PC20<=16 mg/mL
- No more than 1 oral steroid bursts in previous 12 months
- Less that 3 urgent care visit in previous 12 months
- No deterioration with <=25% decrease in steroids
- No near fatal asthma event
Exclusion Criteria:
- Pregnancy
- Current smoker, smoking within the past year or pack/year history >10 years
- Respiratory infection within past 6 weeks
- Antibiotics within the past 6 weeks
- Active lung disease other than asthma
- Cancer within past 5 years (excluding basal cell skin cancer)
- Active or chronic infection
- Hematological or autoimmune disease
- Unable to safely undergo bronchoscopy as determined by doctor or study doctor
We found this trial at
1
site
National Jewish Health National Jewish Health is known worldwide for treatment of patients with respiratory,...
Click here to add this to my saved trials
