The EVICEL® Gastrointestinal Study

This is a single blind, randomized, multi-center controlled study evaluating the safety and
effectiveness of EVICEL® when used as an adjunct to gastrointestinal (GI) surgery.

Inclusion Criteria:

- Subjects undergoing primary elective GI surgery

- Subjects ≥ 18 years of age who are willing to participate in the study and provide
written informed consent prior to any study-related procedures

Exclusion Criteria:

- Avastin use within 30 days prior to surgery;

- Known hypersensitivity to the human blood products or the components of the
investigational product;

- Female subjects who are pregnant or nursing;

- Exposure to another investigational drug or device in a clinical trial within 30 days
prior to surgery or planned/intended for the 90 day follow up period after surgery.