Comparative Effectiveness of MR Enterography



Status:Active, not recruiting
Conditions:Gastrointestinal, Crohns Disease
Therapuetic Areas:Gastroenterology
Healthy:No
Age Range:Any - 18
Updated:4/21/2016
Start Date:May 2011
End Date:May 2016

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Comparative Effectiveness of MR Enterography, Enteric Ultrasound, and Ultrasound Elastography Imaging in the Evaluation of Pediatric Small Bowel Crohn Disease

The purpose of this study is to determine the efficacy of ultrasound imaging compared to MRE
(Magnetic Resonance Enterography) a form of magnetic resonance imaging (MRI) in accurately
diagnosing and following Small Bowel Crohn Disease (SBCD) in children.

Computed Tomography (CT) is an imaging tool that exposes patients to radiation, and until
recently it was the most commonly used imaging method to evaluate small bowel Crohn disease.
Recently, Magnetic Resonance Enterography (MRE) which is a form of magnetic resonance
imaging that provides detailed images of the bowel and less frequently, Ultrasound (US) are
replacing CT as the standard of care imaging tool at some institutions.

The investigators would like to determine how effective US imaging is compared to MRI
imaging in accurately diagnosing and following SBCD in children. Along with enteric
ultrasound (EnUS) we will also be comparing a new ultrasound technology called Ultrasound
Elastography Imaging (UEI) for this study in which we will be using a second form of UEI
called Acoustic Radiation Force Impulse (ARFI). This technique uses sound waves to asses the
stiffness properties of soft tissue. The study will compare costs, patient preferences, and
imaging accuracy.

Inclusion Criteria:

- Pediatric patients under 18 years age.

- Recently diagnosed with small bowel crohn's disease and have not received any prior
treatment for this condition

Exclusion Criteria:

- Are pregnant.

- Require sedation to have the MRE exam.

- Cannot tolerate small enclosed spaces for 60 minutes.

- Have kidneys that are poorly functioning (eGFR <30ml/min)
We found this trial at
1
site
500 S State St
Ann Arbor, Michigan 48109
(734) 764-1817
University of Michigan The University of Michigan was founded in 1817 as one of the...
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from
Ann Arbor, MI
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