How Does Magnesium Status Influence Calcium Homeostasis?
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Endocrine |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 30 - 75 |
| Updated: | 4/21/2016 |
| Start Date: | May 2012 |
| End Date: | April 2016 |
The investigators aim to recruit 60 women who have agreed to participate in an existing
randomized, double-blind, placebo-controlled trial (Treatment of Vitamin D Insufficiency,
HSC 2009-0055). In this trial, the investigators propose to evaluate the associations
between magnesium intake, magnesium stores, fractional magnesium absorption and calcium
homeostasis. The investigators will stratify 60 subjects in the sub-study, ensuring that
approximately 20 subjects are randomized into each treatment arm (placebo, low-dose and
high-dose vitamin D). The investigators already assess calcium homeostasis throughout the
study by measuring bone mineral density, fractional calcium absorption, serum and urine
calcium levels, among other tests. In the sub-study of 60 women, the investigators will
evaluate whether habitually higher magnesium intake increases or decreases fractional
calcium absorption. The investigators will evaluate the interplay between magnesium stores,
vitamin D levels and serum parathyroid hormone levels. The investigators will directly
assess magnesium stores using serum magnesium and 24-hour urine magnesium levels, and will
measure magnesium absorption using the dual stable isotope approach.
randomized, double-blind, placebo-controlled trial (Treatment of Vitamin D Insufficiency,
HSC 2009-0055). In this trial, the investigators propose to evaluate the associations
between magnesium intake, magnesium stores, fractional magnesium absorption and calcium
homeostasis. The investigators will stratify 60 subjects in the sub-study, ensuring that
approximately 20 subjects are randomized into each treatment arm (placebo, low-dose and
high-dose vitamin D). The investigators already assess calcium homeostasis throughout the
study by measuring bone mineral density, fractional calcium absorption, serum and urine
calcium levels, among other tests. In the sub-study of 60 women, the investigators will
evaluate whether habitually higher magnesium intake increases or decreases fractional
calcium absorption. The investigators will evaluate the interplay between magnesium stores,
vitamin D levels and serum parathyroid hormone levels. The investigators will directly
assess magnesium stores using serum magnesium and 24-hour urine magnesium levels, and will
measure magnesium absorption using the dual stable isotope approach.
Use of serum magnesium isotopes to measure fractional magnesium absorption Four day food
diaries to assess magnesium intake Standard urine and serum chemistries for remaining labs
as noted above
diaries to assess magnesium intake Standard urine and serum chemistries for remaining labs
as noted above
Inclusion Criteria:
- participants eligible for the study "Treatment of vitamin D insufficiency" are
eligible for participation in the current sub-study
Exclusion Criteria:
- identical to those covered in HSC #2009-0055
We found this trial at
1
site
Madison, Wisconsin 53705
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