Pharmacokinetics of LCQ908 in Patients With Hepatic Impairment

Inclusion criteria:

Individuals with hepatic impairment only

• Hepatic impairment evidenced by a Child-Pugh score

- Mild hepatic impairment defined Child-Pugh Class A (5-6 points)

- Moderate hepatic impairment defined Child-Pugh Class B (7-9 points)

- Severe hepatic impairment defined Child-Pugh Class C (10-15 points).

Healthy subjects only

• Good health determined.

Exclusion criteria:

All Individuals

- A past medical history of clinically significant ECG abnormalities or a family
history of a prolonged QT-interval syndrome.

- Female subjects must be of non child bearing potential or use an effective method of
contraception.

Individuals with hepatic impairment

- History of drug or alcohol abuse within 3 months prior to dosing.

- History or presence of significant uncontrolled disease of any major organ class.

- Any surgical or medical condition other than hepatic impairment which might alter the
drug metabolism.

Healthy subjects

- History or presence of significant uncontrolled disease of any major organ class.

- Any surgical or medical condition other than hepatic impairment which might alter the
drug metabolism.

- History or presence of hepatitis B or C and/or positive Hepatitis B surface antigen
(HBsAg) or Hepatitis C test result at screening.

Other protocol-defined inclusion/exclusion criteria may apply.