Reading in Preterm and Full-term Children: Neural Basis and Prediction

On the first day we will do the following:

1. We will ask your child to complete standardized tests of language, reading and
intelligence.

2. We will ask you child to do computerized tests about grammar and higher mental
functions, such as memory and planning.

3. While your child is doing tests, you will fill out some questionnaires and answer some
questions about your child's health, behavior, and schooling. You may refuse to answer
any individual question on the questionnaire.

4. We will review your child's medical records. Medical record review is for review of
previous MRI scans and other conditions that might affect your child's ability in this
study.

All participants will undergo the same cognitive and academic test battery initially at age
6 and again at age 8 years old.

On the day of the MRI scanning:

1. A member of the team will ask you and your child medical information to check that it
is okay for your child to be tested.

2. Before your child begins the study, we will ask your child if s/he has had any
medications, alcohol, tobacco, or over-the-counter drugs recently. If your child is
taking stimulants for Attention-Deficit/Hyperactivity Disorder or ADHD (such as
Ritalin, Concerta, Dexedrine, Adderall), antihistamines, pseudoephedrine or Sudafed, we
will ask you to hold these medicines 24 hours before the scan. Your child can take them
after the scan is complete. Deferring stimulants for 24 hours is safe and commonly done
by many children with ADHD on weekends.

3. In the fMRI scanner, your child will lay on a table that slides inside the magnet. A
technician will place your child's head in a head-coil (a helmet-like device) and make
sure that s/he is comfortable. Your child will hold onto a ball that sounds an alarm
when squeezed. This is a signal for the technician to stop the scan, come in to talk
with your child, and take him or her out of the scanner if s/he is unable to continue
with the tests. We will take pictures of the structure of your child's brain. During
this time s/he can watch part of a video of his/her choice or one from our video
library. In order for the brain pictures to come out right, it is very important that
s/he does not move her/his head while inside the scanner. In between tasks, the
technician will talk to your child through a microphone and ask if everything is OK.
Your child should respond in a loud, clear voice without moving his/her head. We hope
your child can complete the testing. Your child can choose to stop the testing at any
time s/he needs to. Your child should tell the technician if anything is uncomfortable.
You may sit in the scanning room if your child wants you to and if you don't have any
metal in your body or any other MRI exclusions.

Inclusion Criteria:

- Pre-terms: PT children born <35 weeks gestation and weighing <2000 grams at birth.

- Full-term: FT participants will be healthy children born ≥ 36 weeks gestation and
weighing ≥ 2750 grams, who are developing typically per pediatrician well-visit
report and match the PT group on age, gender, and SES.

Exclusion Criteria:

- Congenital anomalies or recognizable malformation syndromes

- Mother's self-reported use of illicit drugs or alcohol during pregnancy;

- Birth weight <3rd %tile (small for gestational age, SGA) according to gestational age
specific growth curves;

- Serious neurological problems including active seizure disorder (afebrile seizure
within the last year) and/or anticonvulsant medication use, history of a central
nervous system infections, or ventriculoperitoneal shunt for treatment for
hydrocephalus

- IQ < 70 on the testing of this study because we would expect language delays in this
group;

- Sensori-neural hearing loss, defined as 4-tone pure-tone average > 25 decibels as
assessed at any time because hearing loss compromises language and reading
development;

- Visual impairments that would interfere with the ability to read; (8) presence of any
other health condition that might compromise academic functioning (FT only).

- Any child who has not been learning English either at home or at school for at least
2 years