Potential Molecular Predictors of Response to Novel Therapies in Metastatic Pancreatic Neuroendocrine Tumors

Inclusion Criteria:

- Histopathologic evidence of well differentiated pancreatic NET

- Evidence of measurable disease by RECIST 1.1. Both patients with synchronous disease
and those with prior resected primary cancers will be eligible.

- Patient ≥18 years of age on the day of signing informed consent.

- Planned initiation of active therapy with everolimus ,sunitinib or traditional
cytotoxic chemotherapy.

Patients can be included in this study, regardless of prior therapy, but cannot undergo
concurrent therapy, such as hepatic artery embolization

- Available archival tissue with adequate FFPE tissue for analysis verified by a
pathologist (in cases of biopsies less than 2 cm and/or less than 70% tumor content 10
slides will be required for adequate DNA preparation. For larger biopsies and any
resections, 5 slides are sufficient for DNA extraction).

Exclusion Criteria:

- Patient has a history of a second active malignancy with evidence of metastases.
Patients with a history of resected prior malignancy are allowed.

- Patient has known psychiatric or substance abuse disorders that would, in the opinion
of the treating investigator, interfere with cooperation with the requirements of the
trial.