Brain Energy and Cognition
| Status: | Completed |
|---|---|
| Conditions: | Insomnia Sleep Studies |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - 39 |
| Updated: | 4/2/2016 |
| Start Date: | June 2012 |
| End Date: | June 2015 |
| Contact: | Tracey J Smith, PhD |
| Email: | tracey.j.smith@us.army.mil |
| Phone: | 508-233-4868 |
This proposed laboratory study will extend previous findings on relationships between
cognitive function and nutritional status to conditions that more closely resemble military
operations where aerobic exercise, inadequate nutritional intake and sleep deprivation
combine to degrade cognitive function. The investigators will examine cognitive function,
brain activity and glucose levels in volunteers who are calorie-deprived, performing high
workload cognitive tests, exercising and, in one arm of the study, are sleep-deprived for
approximately 48 hours. A comprehensive cognitive test battery will be repeatedly
administered and several cognitive tests will be administered when volunteers are
exercising. Interstitial glucose levels will be assessed and whole body nitrogen utilization
determined. The effects of energy restriction and the physiological basis of the
relationship between peripheral glucose levels and cognitive function will be examined using
a state-of-the-art imaging technology, functional Magnetic Resonance Imaging (fMRI). This
technique will allow any key brain regions affected by caloric deprivation to be identified.
cognitive function and nutritional status to conditions that more closely resemble military
operations where aerobic exercise, inadequate nutritional intake and sleep deprivation
combine to degrade cognitive function. The investigators will examine cognitive function,
brain activity and glucose levels in volunteers who are calorie-deprived, performing high
workload cognitive tests, exercising and, in one arm of the study, are sleep-deprived for
approximately 48 hours. A comprehensive cognitive test battery will be repeatedly
administered and several cognitive tests will be administered when volunteers are
exercising. Interstitial glucose levels will be assessed and whole body nitrogen utilization
determined. The effects of energy restriction and the physiological basis of the
relationship between peripheral glucose levels and cognitive function will be examined using
a state-of-the-art imaging technology, functional Magnetic Resonance Imaging (fMRI). This
technique will allow any key brain regions affected by caloric deprivation to be identified.
Inclusion Criteria:
- MUST BE ACTIVE DUTY ARMY STATIONED AT NATICK SOLDIER SYSTEMS CENTER
- Fluent in English (non-native English speakers can be enrolled); males and females
aged 18 - 39 years.
Exclusion Criteria:
- Not yet reached 18th birthday, metal implants - which can interfere with fMRI
scanning; fear of small places; pregnant (USARIEM will test for pregnancy), Attention
Deficit Hyperactivity Disorder (ADHD) - if previously documented by a waiver; acute
or chronic physical limitation that would hinder performing cycle exercise; known
allergies to medical adhesives.
We found this trial at
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