Taurine Therapy for SSADH Deficiency
| Status: | Completed |
|---|---|
| Conditions: | Other Indications |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 12 - Any |
| Updated: | 4/5/2019 |
| Start Date: | April 27, 2012 |
| End Date: | December 16, 2013 |
Succinic Semialdehyde Dehydrogenase Deficiency: Physiological Markers of Taurine Therapy
Background:
- Succinic semialdehyde dehydrogenase (SSADH) deficiency is a rare genetic disease that
results in changes to certain brain chemicals. These chemicals may affect brain excitability,
or how likely nerve cells are to turn on. Changes in brain excitability may help to explain
the symptoms of the disease, including learning and memory problems, seizures, and poor
balance. A supplement called taurine may help people with SSADH deficiency by working on the
brain chemical GABA. GABA helps to regulate brain activity. Researchers want to see if
taurine can help people with SSADH deficiency.
Objectives:
- To learn more about how taurine affects the brain in people with SSADH deficiency.
Eligibility:
- Individuals at least 12 years of age who have SSADH deficiency.
Design:
- Participants will be screened with a physical exam and medical history. They will
provide blood and urine samples. They will also take taurine supplements as part of this
protocol.
- Participants will have two sets of study tests. One set will be given while participants
are taking taurine. The second will be given when they are not taking it. Each testing
session will take about 2 days to complete.
- Half of the participants will have the "off taurine" testing before starting on the
taurine supplement. The other half will start taking taurine first, have the "on
taurine" testing, and have the "off taurine" testing about 3 months after stopping
taurine. Participants may decide the order in which they will have the testing done.
- Participants will have the following tests at the two test visits:
- Paper and pencil tests of learning and memory.
- Transcranial magnetic stimulation to study the excitability of nerve cells.
- Imaging studies to show GABA receptors in the brain and measure their activity.
- Electroencephalogram to measure brain waves.
- Lumbar puncture to collect spinal fluid.
- Participants will be monitored with regular study visits while they receive the taurine
supplement treatment.
- Succinic semialdehyde dehydrogenase (SSADH) deficiency is a rare genetic disease that
results in changes to certain brain chemicals. These chemicals may affect brain excitability,
or how likely nerve cells are to turn on. Changes in brain excitability may help to explain
the symptoms of the disease, including learning and memory problems, seizures, and poor
balance. A supplement called taurine may help people with SSADH deficiency by working on the
brain chemical GABA. GABA helps to regulate brain activity. Researchers want to see if
taurine can help people with SSADH deficiency.
Objectives:
- To learn more about how taurine affects the brain in people with SSADH deficiency.
Eligibility:
- Individuals at least 12 years of age who have SSADH deficiency.
Design:
- Participants will be screened with a physical exam and medical history. They will
provide blood and urine samples. They will also take taurine supplements as part of this
protocol.
- Participants will have two sets of study tests. One set will be given while participants
are taking taurine. The second will be given when they are not taking it. Each testing
session will take about 2 days to complete.
- Half of the participants will have the "off taurine" testing before starting on the
taurine supplement. The other half will start taking taurine first, have the "on
taurine" testing, and have the "off taurine" testing about 3 months after stopping
taurine. Participants may decide the order in which they will have the testing done.
- Participants will have the following tests at the two test visits:
- Paper and pencil tests of learning and memory.
- Transcranial magnetic stimulation to study the excitability of nerve cells.
- Imaging studies to show GABA receptors in the brain and measure their activity.
- Electroencephalogram to measure brain waves.
- Lumbar puncture to collect spinal fluid.
- Participants will be monitored with regular study visits while they receive the taurine
supplement treatment.
Objective: To study the physiologic effects of taurine therapy in patients with succinic
semialdehyde Dehydrogenase (SSADH) deficiency.
Study Population: Eighteen children and adults with SSADH deficiency receiving taurine.
Design: This small open label trial will evaluate the effect of taurine treatment on key
SSADH biomarkers and neurocognitive performance. Study evaluations will include neurological
and neuropsychological examinations, positron emission tomography (PET) with 11C-flumazenil
(FMZ), (optional and only for those over age 18), magnetic resonance spectroscopy (MRS)
(optional) and cerebrospinal fluid (CSF) collection (optional) to measure gamma-aminobutyric
acid (GABA) levels, and transcranial magnetic stimulation (TMS) to measure cortical
excitation and inhibition, in patients given taurine for SSADH deficiency.
The evaluations will be performed twice, on and off therapy.
semialdehyde Dehydrogenase (SSADH) deficiency.
Study Population: Eighteen children and adults with SSADH deficiency receiving taurine.
Design: This small open label trial will evaluate the effect of taurine treatment on key
SSADH biomarkers and neurocognitive performance. Study evaluations will include neurological
and neuropsychological examinations, positron emission tomography (PET) with 11C-flumazenil
(FMZ), (optional and only for those over age 18), magnetic resonance spectroscopy (MRS)
(optional) and cerebrospinal fluid (CSF) collection (optional) to measure gamma-aminobutyric
acid (GABA) levels, and transcranial magnetic stimulation (TMS) to measure cortical
excitation and inhibition, in patients given taurine for SSADH deficiency.
The evaluations will be performed twice, on and off therapy.
- INCLUSION CRITERIA:
Persistent 4-hydroxybutyric aciduria (gamma-hydroxybutyric aciduria).
Documented succinic semialdehyde dehydrogenase enzyme deficiency.
Patients will be at least 12 years old.
Be enrolled in the taurine study at CNMC.
EXCLUSION CRITERIA:
Pregnancy or lactation.
Patients with a history of other significant medical disorders.
Patients requiring treatment with drugs known to affect the GABAergic system, including
vigabatrin, barbiturates, and benzodiazepines.
Hearing loss. The effect of TMS on hearing is not fully known. Patients will be screened
with an Audiometer.
Abnormal platelets or coagulation studies suggesting increased risk for lumbar puncture or
TMS
Exclusions for MRI and MRS: pacemakers or other implanted electrical devices, brain
stimulators, some types of dental implants, aneurysm clips (metal clips on the wall of a
large artery), metallic prostheses (including metal pins and rods, heart valves, and
cochlear implants), permanent eyeliner, implanted delivery pump, or shrapnel fragments,
welders and metal workers.
Exclusions for TMS: people with implanted medical devices such as pacemakers, implanted
pumps, stimulators, or cochlear implants or in people who have metal objects inside the eye
or skull.
We found this trial at
1
site
9000 Rockville Pike
Bethesda, Maryland 20892
Bethesda, Maryland 20892
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