Pilot Study of Lymphoid Tumor Microenvironmental Dysruption Prior to Autologous Stem Cell Transplantation
| Status: | Terminated |
|---|---|
| Conditions: | Blood Cancer, Lymphoma, Hematology |
| Therapuetic Areas: | Hematology, Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | July 2013 |
| End Date: | September 2017 |
In order to keep our immune systems healthy over our lifetime, certain cells in the bone
marrow and lymph nodes called stromal cells nurture the immune cells and protect them from
damage. Stromal cells and blood cells communicate using a protein called SDF1a. The
investigators think that cancer cells including lymphoma and multiple myeloma can trick the
stromal cells into helping them avoid damage from chemotherapy by using SDF1a.
Plerixafor is a drug developed to block the effects of SDF1a and has been approved by the
Federal Drug Administration (FDA) for use in humans to help release blood stem cells from
the bone marrow for use in transplantation. The use of plerixafor to interrupt communication
between stromal cells and cancer has not been approved by the FDA and is experimental.
marrow and lymph nodes called stromal cells nurture the immune cells and protect them from
damage. Stromal cells and blood cells communicate using a protein called SDF1a. The
investigators think that cancer cells including lymphoma and multiple myeloma can trick the
stromal cells into helping them avoid damage from chemotherapy by using SDF1a.
Plerixafor is a drug developed to block the effects of SDF1a and has been approved by the
Federal Drug Administration (FDA) for use in humans to help release blood stem cells from
the bone marrow for use in transplantation. The use of plerixafor to interrupt communication
between stromal cells and cancer has not been approved by the FDA and is experimental.
Inclusion Criteria:
- Age 18 years or older
- Subjects must have documented, relapsed/refractory or high-risk primary lymphoid
malignancy
- Subjects must have evidence of residual disease prior to transplant, but need not
have measurable or strictly evaluable disease
- Subjects must be eligible candidates for high dose chemotherapy with either BEAM or
single-agent melphalan preparative regimens and autologous stem cell transplantation
at Tufts Medical Center (See Appendix B for anticipated transplant schedules)
- Subjects must be able to provide informed consent to the research procedure
Exclusion Criteria:
- Uncontrolled infection
- Active heart disease as evidenced by myocardial infarction within 6 months,
uncontrolled arrhythmia, or angina.
- Creatinine clearance estimated < 50 ml/min.
- HIV infection or evidence of active chronic hepatitis
- Unable or unwilling to comply with required study procedures
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