Methylselenocysteine Effects on Circadian Rhythm
| Status: | Completed |
|---|---|
| Conditions: | Breast Cancer, Prostate Cancer, Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 21 - 60 |
| Updated: | 9/13/2017 |
| Start Date: | October 2011 |
| End Date: | June 2015 |
Chemoprevention of Breast and Prostate Cancers in Shift Workers by Dietary Methylselenocysteine: Effects on Circadian Rhythm and Estrogen Receptor-B Cycling
The primary objective of this study is to determine if vitamin supplementation with a
naturally occurring dietary amino acid called organic selenium (i.e., methylselenocysteine)
can restore disruption of circadian rhythm in shift workers.
naturally occurring dietary amino acid called organic selenium (i.e., methylselenocysteine)
can restore disruption of circadian rhythm in shift workers.
All living cells have a circadian (daily) rhythm which controls a variety of bodily functions
that change throughout the day, including body temperature, sleep, hunger, activity, hormone
levels, etc. The circadian rhythm of the body is controlled by the amount of light that
enters our eyes, so on our planet the length of the rhythm is 24 hours long. It is therefore
reasonable to suspect that upsetting the timing of the rhythm would lead to changes in body
function (as commonly experienced in "jet lag") and that prolonged changes might even lead to
alterations in bodily functions and contribute to disease. This suggests that people whose
service to the community that requires that they often work at night (nurses, doctors,
police, hospital staff, firefighters, airline crews, factory workers, etc), might be at
elevated risk of developing diseases. Studies have shown that women who do shift work have an
elevated risk of breast cancer, probably as a result of altered hormone levels and cycling.
Other studies have shown that vitamin supplementation with a naturally occurring dietary
amino acid called organic selenium (i.e., methylselenocysteine) can restore this disrupted
rhythm and possibly decrease this disease risk. Thus, the purpose of this study is to
investigate whether taking daily selenium (i.e., methylselenocysteine) will restore the
disrupted circadian rhythm in shift workers.
that change throughout the day, including body temperature, sleep, hunger, activity, hormone
levels, etc. The circadian rhythm of the body is controlled by the amount of light that
enters our eyes, so on our planet the length of the rhythm is 24 hours long. It is therefore
reasonable to suspect that upsetting the timing of the rhythm would lead to changes in body
function (as commonly experienced in "jet lag") and that prolonged changes might even lead to
alterations in bodily functions and contribute to disease. This suggests that people whose
service to the community that requires that they often work at night (nurses, doctors,
police, hospital staff, firefighters, airline crews, factory workers, etc), might be at
elevated risk of developing diseases. Studies have shown that women who do shift work have an
elevated risk of breast cancer, probably as a result of altered hormone levels and cycling.
Other studies have shown that vitamin supplementation with a naturally occurring dietary
amino acid called organic selenium (i.e., methylselenocysteine) can restore this disrupted
rhythm and possibly decrease this disease risk. Thus, the purpose of this study is to
investigate whether taking daily selenium (i.e., methylselenocysteine) will restore the
disrupted circadian rhythm in shift workers.
Inclusion Criteria:
- Permanent night shift schedule
Exclusion Criteria:
- Nutritional supplements that contain selenium
- Pregnant
- Breast feeding
- Heart conditions
- Chronic lung disease
- Cancer therapy (current or past)
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