Antiplatelet Therapy Guided by Thrombelastography in Patients With Acute Coronary Syndromes (TEGCOR Study)
| Status: | Terminated |
|---|---|
| Conditions: | Peripheral Vascular Disease, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 21 - 75 |
| Updated: | 4/28/2018 |
| Start Date: | August 2011 |
| End Date: | March 2017 |
Personalized treatment approaches and antiplatelet drug choice have been proposed to optimize
safety of coronary stenting by reducing heart attacks and repeat interventions while
simultaneously minimizing adverse bleeding events. This study compares the efficacy of two
laboratory guided treatment algorithms to personalize antiplatelet medication choice after
coronary stenting
safety of coronary stenting by reducing heart attacks and repeat interventions while
simultaneously minimizing adverse bleeding events. This study compares the efficacy of two
laboratory guided treatment algorithms to personalize antiplatelet medication choice after
coronary stenting
Inclusion Criteria:
- Patients admitted with acute coronary syndrome (unstable angina, non-ST elevation
myocardial infarction) and referred for coronary angiography.
- Current therapy with clopidogrel (at least 300mg loading dose, or 75mg po daily for >5
days)
- Age range 21-75 years.
Exclusion Criteria:
- Unable to give consent
- Age younger than 21 years, greater than 75 years
- History of stroke
- Body weight <60 kg
- Acute STEMI,
- Thrombocytopenia<100'000,
- requirement for chronic warfarin therapy
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