Dose Range Study of CD5789 in Acne Vulgaris

Inclusion Criteria:

- Male or female subject, 12 to 35 years old with the following characteristics:

- Facial acne severity grade of the following:

- Stratum 1: IGA score of 3 or 4

- Stratum 2: IGA score of 4

- Stratum 3: IGA score of 3 or 4

- A minimum of 30 non-inflammatory lesions and fulfills the criteria of one of the
following strata:

- Stratum 1: A minimum of 20 but not more than 40 inflammatory lesions, and a
maximum of one nodule on the face.

- Stratum 2: More than 40 inflammatory lesions, and up to four nodules on the
face.

- Stratum 3: Subjects of Japanese origin with at least 20 inflammatory lesions and
up to four nodules on the face.

- Note: Subjects of Japanese origin will not be included in Stratum 1 or
Stratum 2. Japanese origin is defined as all four grandparents were born in
Japan.

Exclusion Criteria:

- The presence of severe forms of acne (acne conglobata, acne fulminans) or secondary
acne form (chloracne, drug-induced acne, etc.)

- Any uncontrolled or serious disease, or any medical or surgical condition, that may
either interfere with the interpretation of the clinical trial results and/or put the
subject at significant risk (according to the Investigator's judgment) if the subject
participates in the clinical trial.

- Known or suspected allergies or sensitivities to any components of any of the study
drugs.

- Current participation in any other clinical trial of a drug or device OR past
participation within the 30 days prior to the Baseline visit.