Continuous Renal Replacement Therapy in the Setting of Orthotopic Liver Transplant
| Status: | Recruiting |
|---|---|
| Conditions: | Renal Impairment / Chronic Kidney Disease, Hospital, Gastrointestinal |
| Therapuetic Areas: | Gastroenterology, Nephrology / Urology, Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 7/11/2015 |
| Start Date: | April 2012 |
| Contact: | Jay Koyner, MD |
| Email: | jkoyner@medicine.bsd.uchicago.edu |
| Phone: | 773-702-4842 |
Continuous Renal Replacement Therapy in the Setting of Orthotopic Liver Transplant: A Randomized Trial
To evaluate the efficacy of continuous renal replacement therapy (CRRT) during orthotopic
liver transplantation (OLT) in clearing excess solutes and improving acid-base parameters.
The investigators hypothesize that the use of intra-operative CRRT in OLT recipients is
associated with increased solute removal and improved acid-base statues when compared to
controls who do not receive CRRT
liver transplantation (OLT) in clearing excess solutes and improving acid-base parameters.
The investigators hypothesize that the use of intra-operative CRRT in OLT recipients is
associated with increased solute removal and improved acid-base statues when compared to
controls who do not receive CRRT
as above
Inclusion Criteria:
- Age 18 or older and able to sign consent (or surrogate)
- Receiving liver or combined liver-kidney transplant
- eGFR < or equal to 40 ml/min immediately prior to transplant or currently on any form
of renal replacement therapy for acute kidney injury or end-stage renal disease
- Pre-operative potassium of < or equal to 5.5 mEq/L
Exclusion Criteria:
- Pre-operative hemoglobin < or equal to 7 g/dL
- Pre-operative weight > or equal to 125 kig
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