Brain Imaging Plus Urodynamics to Investigate the Brain's Control of the Bladder

Inclusion Criteria:

- ambulatory women over age 60, who are incontinent at least five times weekly for 3
months despite correction of potentially reversible causes.

- urinary incontinence (urge or predominantly urge) by clinical criteria.

- able to accurately complete a voiding diary, to perform a 24-hour pad test under
direction.

Exclusion Criteria:

- significant mental impairment [mini mental status exam (MMSE) ≤ 20)

- urethral obstruction

- history of bladder cancer

- spinal cord lesions

- multiple sclerosis

- pelvic radiation

- interstitial cystitis

- artificial sphincter implant

- expected to have changes in medications/doses during the trial

- medically unstable

- Patients with factors that could cause transient UI [e.g., current urinary tract
infection (UTI), acute confusion] will be treated in concert with the subject's
primary care provider and considered for enrollment if their UI persists.

- conditions that require endocarditis prophylaxis (such as heart valve problems or
bacterial endocarditis)