MR(Magnetic Resonance) Imaging of Neurotransmitters in Chronic Pain
| Status: | Terminated |
|---|---|
| Conditions: | Arthritis, Back Pain, Diabetic Neuropathy, Osteoarthritis (OA), Neurology |
| Therapuetic Areas: | Endocrinology, Musculoskeletal, Neurology, Rheumatology |
| Healthy: | No |
| Age Range: | 30 - 70 |
| Updated: | 6/6/2018 |
| Start Date: | September 2012 |
| End Date: | June 7, 2017 |
MR (Magnetic Resonance) Imaging of the Excitatory and Inhibitory Neurotransmitters in Chronic Pain
This study is designed to assess:
Hypothesis #1: That there is a significant central pain component in a distinct subset of
patients diagnosed with knee osteoarthritis(KOA), Chronic low back pain(CLBP), painful
diabetic neuropathy(PDN.)
Hypothesis # 2: To establish a reliable strategy for differentiation of central pain
predominant from peripheral pain predominant knee osteoarthritis(KOA), chronic low back
pain(CLBP)and peripheral diabetic neuropathy(PDN) patients using clinical features,
experimental pain testing and magnetic resonance(MR) Spectroscopy.
Hypothesis #1: That there is a significant central pain component in a distinct subset of
patients diagnosed with knee osteoarthritis(KOA), Chronic low back pain(CLBP), painful
diabetic neuropathy(PDN.)
Hypothesis # 2: To establish a reliable strategy for differentiation of central pain
predominant from peripheral pain predominant knee osteoarthritis(KOA), chronic low back
pain(CLBP)and peripheral diabetic neuropathy(PDN) patients using clinical features,
experimental pain testing and magnetic resonance(MR) Spectroscopy.
This study will identify clinical and neuroimaging markers in chronic pain in an effort to
provide individual-based treatments. This study will differentiate chronic pain subjects
(knee osteoarthritis, low back pain and painful diabetic neuropathy) into two groups: those
who have central pain predominant symptoms and those who have peripheral pain predominant
symptoms. The response to medical treatment between these two groups is quite different, thus
a reliable strategy to correctly categorize chronic pain sufferers offers the opportunity to
provide targeted, effective treatments. Chronic pain is a prevalent problem in the VA veteran
population with significant associated costs; in particular knee osteoarthritis, chronic low
back pain and painful diabetic neuropathy are common in this population. The proposed study
will use different clinical pain tests and advanced neuroimaging techniques to improve our
understanding of chronic pain and improve patient outcomes.
provide individual-based treatments. This study will differentiate chronic pain subjects
(knee osteoarthritis, low back pain and painful diabetic neuropathy) into two groups: those
who have central pain predominant symptoms and those who have peripheral pain predominant
symptoms. The response to medical treatment between these two groups is quite different, thus
a reliable strategy to correctly categorize chronic pain sufferers offers the opportunity to
provide targeted, effective treatments. Chronic pain is a prevalent problem in the VA veteran
population with significant associated costs; in particular knee osteoarthritis, chronic low
back pain and painful diabetic neuropathy are common in this population. The proposed study
will use different clinical pain tests and advanced neuroimaging techniques to improve our
understanding of chronic pain and improve patient outcomes.
Inclusion Criteria:
- Must be Right Handed.
(Chronic Pain with knee osteoarthritis)
- Diagnosed with: unilateral, symptomatic knee osteoarthritis based on American College
of Rheumatology (ACR) criteria.
- Have had a knee x-ray within the last 6 months.
- Must have average pain intensity of 4 or greater on a 0 (no pain) to 10 (worst pain
imaginable) scale.
(Chronic Low Back Pain)
- Have primary complaint of constant or intermittent back pain of at least 6 months
duration.
- Have a Roland Morris Disability Questionnaire score of >7.
(Diabetes Mellitus with Painful Peripheral Neuropathy)
- Have a diagnosis of diabetes mellitus for at least 6 months.
- Have a diagnosis of diabetic peripheral neuropathy.
- Have had Electromyography(EMG) testing within the last 6 months.
- Have a >40 mm score on the short-form McGill Pain questionnaire.
(Healthy controls)
- Must be pain free
- No history of neurological or psychiatric illness.
- No diagnosis of Diabetes Mellitus.
- No evidence of neuropathy on clinical assessment.
Exclusion Criteria:
- Being pregnant.
- Have metal in the body or other contraindications to Magnetic Resonance Imaging (MRI).
- Have a chronic pain condition unrelated to knee osteoarthritis, chronic low back pain
or diabetes.
- Have currently or a history of brain infection, stroke or tumor.
- Have a risk factor for other non-diabetic neuropathies
We found this trial at
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