Evaluating New Radiation Techniques for Cardiovascular Imaging
| Status: | Recruiting |
|---|---|
| Conditions: | Peripheral Vascular Disease, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - 100 |
| Updated: | 3/27/2019 |
| Start Date: | July 31, 2012 |
| Contact: | Marsha Block, R.N. |
| Email: | blockma@mail.nih.gov |
| Phone: | (301) 496-0211 |
Prospective Evaluation of New Techniques in Radiation Reduction for Cardiovascular Computed Tomographic Angiography
Title: Evaluating New Radiation Techniques for Cardiovascular Imaging
Background:
- Imaging studies such as computed tomography (CT) scans involve the use of radiation to
create the pictures. Heart and blood vessel CT scans can cause high radiation exposure.
Different methods of creating CT pictures have been developed to reduce the radiation dose.
Researchers want to see how effective these new methods are in producing accurate CT scans.
Objectives:
- To study new ways of taking pictures of the heart or blood vessels using computed
tomography.
Eligibility:
- Adults at least 18 years of age who will be having imaging studies to help detect heart or
blood vessel problems.
Design:
- Participants will be screened with a physical exam and medical history. Blood samples
will be taken to check kidney function.
- Participants will have a CT scan of the heart and blood vessels. A contrast agent may be
used to improve the quality of the images. The scanning session may last up to 2 hours.
- Participants will have follow-up contact 90 days after the scan, and then yearly contact
for the next 5 years.
Background:
- Imaging studies such as computed tomography (CT) scans involve the use of radiation to
create the pictures. Heart and blood vessel CT scans can cause high radiation exposure.
Different methods of creating CT pictures have been developed to reduce the radiation dose.
Researchers want to see how effective these new methods are in producing accurate CT scans.
Objectives:
- To study new ways of taking pictures of the heart or blood vessels using computed
tomography.
Eligibility:
- Adults at least 18 years of age who will be having imaging studies to help detect heart or
blood vessel problems.
Design:
- Participants will be screened with a physical exam and medical history. Blood samples
will be taken to check kidney function.
- Participants will have a CT scan of the heart and blood vessels. A contrast agent may be
used to improve the quality of the images. The scanning session may last up to 2 hours.
- Participants will have follow-up contact 90 days after the scan, and then yearly contact
for the next 5 years.
Cardiac CT angiography is associated with radiation exposure. Different methods of creating
CT pictures have been developed to reduce the radiation dose to the subject. The purpose of
this research study is to learn whether these new imaging methods are accurate or predict
subject outcomes.
CT pictures have been developed to reduce the radiation dose to the subject. The purpose of
this research study is to learn whether these new imaging methods are accurate or predict
subject outcomes.
- INCLUSION CRITERIA:
1. Clinical indication for a coronary CT angiography exam
2. Age equal to or greater than 18 years
3. Able to understand and willing to sign the Informed Consent Form
4. Able and willing to provide follow-up information in 90 days and yearly for up to
5 years
EXCLUSION CRITERIA:
1. Pregnancy
2. Severe renal excretory dysfunction, estimated glomerular filtration rate < 30
mL/min/1.73m2 body surface area according to the Modification of Diet in Renal Disease
criteria or as reported by the clinical lab. Glomerular filtration rate will be
estimated using the MDRD 2005 revised study formula: eGFR (mL/min/1.73m2) = 175 x
(standardized serum creatinine)-1.154 x (age)-0.203 x 0.742 (if the subject is female)
or x 1.212 (if the subject is black)
We found this trial at
1
site
9000 Rockville Pike
Bethesda, Maryland 20892
Bethesda, Maryland 20892
Phone: 800-411-1222
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