The Longitudinal CONQUER Study of Rare Neuroimmunologic Disorders

This study seeks to determine the biologic causes of inflammation in patients with
Neuromyelitis Optica (NMO), Transverse Myelitis (TM), optic neuritis (ON), related conditions
and healthy controls. While patients will be treated according to decisions with their
treating physician, this study will collect data and samples from patients prospectively to
gain a better understanding of the disease. We are seeking to understand why some patients
respond to medications, while others do not. We also seek to understand what happens
biologically, preceding relapses. Gathering these data and samples will allow researchers to
identify new ways of diagnosing and treating these diseases. Data and samples will be shared
with researchers around the world to support collaborative efforts to treat these conditions.

Patients will agree to share medical records, complete questionnaires and donate samples on a
timed basis.

Inclusion Criteria:

- Age 6 years or greater

- Male or Female

- Patient or Parent (in the case of a minor) able to give informed consent

- For patients 10 to 17, patient able to assent

- Patient diagnosed with NMO, NMOSD, TM or ON

Exclusion Criteria:

- Unable to maintain scheduled visits

- Patient has known HIV or hepatitis C infection