Effect of Thymosin Beta 4 on Wound Healing in Patients With Epidermolysis Bullosa



Status:Archived
Conditions:Skin and Soft Tissue Infections
Therapuetic Areas:Dermatology / Plastic Surgery
Healthy:No
Age Range:Any
Updated:7/1/2011

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Trial Summary
Trial Overview
Inclusion Criteria

A Randomized, Double-Blind, Placebo-Controlled, Dose-Response Study of the Safety and Efficacy of Thymosin Beta 4 in the Treatment of Patients With Epidermolysis Bullosa


The purpose of this study is to investigate a treatment to enhance the healing of acute and
chronic nonhealing cutaneous wounds, such as the erosions experienced by patients with
Epidermolysis Bullosa (EB), by the known activity of thymosin beta 4 (Tβ4).


EB is a group of genetic diseases characterized by skin-blistering and lesion-formation
after minor trauma to the skin. This family of disorders, most of which are inherited, range
in severity from mild to the severely disabling and life-threatening. Tβ4 is a
synthetically-produced copy of a naturally-occurring 43 amino acid peptide that has wound
healing and anti-inflammatory properties and can up-regulate the expression of laminin-5.


We found this trial at
12
sites
Virginia Clinical Research, Inc.
Norfolk, Virginia 23507
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University of Alabama at Birmingham
1720 2nd Ave S
Birmingham, Alabama 35233
(205) 934-4011 
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
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Birmingham, AL
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Vanderbilt University Medical Center
1211 Medical Center Dr
Nashville, Tennessee 37232
(615) 322-5000
Vanderbilt Univ Med Ctr Vanderbilt University Medical Center (VUMC) is a comprehensive healthcare facility dedicated...
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Washington University
1 Brookings Drive
St. Louis, Missouri 63110
 (314) 935-5000
Washington University Washington University creates an environment to encourage and support an ethos of wide-ranging...
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St. Louis, MO
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Northwestern University Feinberg School of Medicine Dept of Dermatology
Chicago, Illinois 60614
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Chicago, IL
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St Vincent Health Center
Erie, Pennsylvania 16544
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Erie, PA
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University of Miami Hospital
1400 NW 12th Ave
Miami, Florida 33136
(305) 689-5511
University of Miami Hospital The University of Miami changed the face of modern health care...
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Miami, FL
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Columbia Presbyterian Med Ctr
722 W 168th St
New York, New York 10032
(212) 305-2500
Columbia Presbyterian Med Ctr On January 1, 1998, The New York Hospital publicly announced its...
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Strong Memorial Hospital (University of Rochester School of Medicine)
601 Elmwood Ave
Rochester, New York 14642
(585) 275-2100
Strong Memorial Hospital (University of Rochester School of Medicine) In addition to offering traditional and...
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Rochester, NY
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Children's Hospital San Diego & University of California San Diego
San Diego, California 92123
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San Diego, CA
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Stanford university Hospital and Clinics
300 Pasteur Dr
Stanford, California 94305
(650) 723-4000
Stanford university Hospital and Clinics Throughout our history, we have pioneered medical advances that save...
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Stanford, CA
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University of Massachusetts Worcester
Worcester, Massachusetts 01605
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Worcester, MA
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