AMPED Outcomes Registry of Post-ED Pain Management

Multicenter, observational, prospective, out-of-hospital registry collecting clinical,
satisfaction, quality of life, and healthcare resource utilization from subjects discharged
after ED care for a specific acute pain syndrome with a clinician-determined analgesic
regimen. Subjects are stratified by diagnosis and by regimen based on the treating
clinician's judgment. The registry study is independent of ED care and clinician's
decision-making.

Inclusion Criteria:

- Eligible subjects will meet the following criteria:

1. Eligible diagnoses:

musculoskeletal etiologies: acute extremity fractures sprains/strains acute gouty
arthritis visceral etiologies: renal colic dysmenorrhea

2. Age GTE 18 years;

3. Decision to discharge from ED to community already made;

4. Decision to give SPRIX, opioid, OR SPRIX + opioid rescue already made;

5. Treating clinician deems patient appropriate for continued analgesic management
as an outpatient for the next 3-5 days;

6. Patient has ready touch-tone (mobile or land line) telephone access, provides
number (and back-up number, if possible) and agrees (verbal or written consent as
mandated by site) to answer and comply with brief IVR questionnaires daily for
next 4 days.

Exclusion Criteria:

- Eligible subjects will meet none of the following criteria:

1. Patient admitted or placed on observation status from ED;

2. Patient unwilling or unable to comply with telephonic follow-up;

3. Fracture that requires surgical repair (even if at a later date);

4. Patient has diagnosis of any chronic pain syndrome;

5. Patient already routinely takes NSAID or opioid agent;

6. Treating clinician has reasonable suspicion of drug-seeking behavior or
noncompliance;

7. Nasal abnormality or illness that could affect the absorption of intranasal
medication (such as: nasal discharge, rhinitis, acute upper respiratory
infection, acute epistaxis, nasal polyp, nasal tumor).