Measurement of Eye Blood Flow and Renal Function in Healthy and Diabetic Patients



Status:Recruiting
Conditions:Healthy Studies, Diabetes, Diabetes
Therapuetic Areas:Endocrinology, Other
Healthy:No
Age Range:18 - 75
Updated:9/21/2018
Start Date:May 2012
End Date:September 2019
Contact:Ebrahim Barkoudah, M.D.,M.P.H.
Email:ebarkoudah@partners.org
Phone:617-732-6901

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Trial Summary
Trial Overview
Inclusion Criteria

Eye Blood Flow and the Kidney

The purpose of this study is to the determine the effect of salt intake and Captopril on the
ophthalmic artery (OA) blood supply of individuals with Type 2 Diabetes Mellitus.

The overall objective of this study is to ascertain if salt intake affects ophthalmic artery
(OA) blood flow. In addition, we will study both the eye and kidney response to ACE
inhibition compared to placebo while controlling salt intake in subjects with Type 2 diabetes
mellitus.

We hypothesize that salt intake will affect OA blood flow.

We will initially look at both eye and renal response to subjects on a low salt diet (10mEq
Na/day) followed by response to high salt diet (200mEq Na/day). In addition, we may look at
eye response while subjects consume their regular diet.

Inclusion Criteria:

- Type 2 Diabetes Mellitus

Exclusion Criteria:

- Type 1 Diabetes Mellitus

- Heart Attack or Stroke within the last 6 months

- Pregnant or lactating females
We found this trial at
1
site
Brigham and Women's Hosp
75 Francis street
Boston, Massachusetts 02115
(617) 732-5500
Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
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from
Boston, MA
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