Feasibility of Intraoperative Optical Imaging and Spectroscopy in Brain Tumors

PRIMARY OBJECTIVES:

I. To develop the instrumentation to achieve real time processing and display of
intraoperative 2-dimensional optical imaging and spectroscopy (i2DOS) maps in the operating
arena.

II. To examine the timing and spatial involvement of human cortex intraoperatively to
different stimuli using i2DOS.

OUTLINE: Patients undergo i2DOS.

Inclusion Criteria:

- Neurosurgical patient population in the City of Hope brain and spinal tumor
neurosurgical programs that have been diagnosed with a brain tumor.

- Only lucid patients qualified to consent to neurosurgical procedure will be
approached for participation in this study.

- We do intend to enroll subjects with potentially terminal brain tumors. Due to the
potential benefit of intraoperative mapping, we are not planning to exclude these
subjects.

- Patients with any type of brain tumor will be eligible for participation.

- All subjects must have the ability to understand and the willingness to sign a
written informed consent.

Exclusion Criteria:

- There are no exclusion criteria except for individuals without a brain tumor and the
location of the craniotomy. If the exposed area of brain is not compatible with
peripheral stimuli or volitional activity the subject cannot be enrolled.

- Subjects, who in the opinion of the investigator, may not be able to comply with the
safety monitoring requirements of the study.