Vascular Impairment in Type II Diabetes Mellitus With Co-morbid Obstructive Sleep Apnea



Status:Completed
Conditions:Insomnia Sleep Studies, Pulmonary, Diabetes
Therapuetic Areas:Endocrinology, Psychiatry / Psychology, Pulmonary / Respiratory Diseases
Healthy:No
Age Range:18 - 70
Updated:4/17/2018
Start Date:April 2012
End Date:February 2017

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Trial Summary
Trial Overview
Inclusion Criteria

Vascular Impairment in Type II Diabetes Mellitus With Co-morbid Obstructive Sleep Apnea.

The investigators will examine the possible synergistic effects of obstructive sleep apnea
(OSA) and type II diabetes mellitus (DM) on vascular functioning by performing a two-part
investigation:

- A cross-sectional study comparing subjects with OSA+DM, OSA only, DM only, and healthy
controls.

- A three-month randomized placebo-controlled trial of continuous positive airway pressure
(CPAP) in subjects with OSA+DM.


Inclusion Criteria:

- OSA subjects: apnea-hypopnea index >=10 and <100

- DM subjects: clinical diagnosis of DM and glycated hemoglobin < 8.0%

Exclusion Criteria:

- Hematocrit < 32

- Pregnancy

- Infectious/collagen vascular/hepatic or renal/cardiopulmonary disease
We found this trial at
2
sites
Beth Israel Deaconess Medical Center
330 Brookline Ave
Boston, Massachusetts 02215
617-667-7000
Principal Investigator: Aristidis Veves, MD
Phone: 617-632-7075
Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
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Boston, MA
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Brigham and Women's Hosp
75 Francis street
Boston, Massachusetts 02115
(617) 732-5500
Principal Investigator: Jessie P Bakker, PhD
Phone: 617-732-5987
Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
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Boston, MA
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