The Effects of Smoking Withdrawal On Resting State Functional Connectivity
| Status: | Withdrawn |
|---|---|
| Conditions: | Smoking Cessation |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - 55 |
| Updated: | 2/1/2017 |
| Start Date: | February 2012 |
| End Date: | September 2012 |
The Effects of Smoking Withdrawal on Resting State Functional Connectivity
The purpose of this study is to see how the brain differs between smoking regularly and
after not smoking for 24 hours. The investigators will be using an MRI machine to get the
information from adult smokers and non-smokers while they lie in the scanner with their eyes
closed. Smokers will be scanned when they have not smoked for 24 hrs and shortly after
smoking. It is our hypothesis that brain activity will be altered after not smoking for 24
hours.
after not smoking for 24 hours. The investigators will be using an MRI machine to get the
information from adult smokers and non-smokers while they lie in the scanner with their eyes
closed. Smokers will be scanned when they have not smoked for 24 hrs and shortly after
smoking. It is our hypothesis that brain activity will be altered after not smoking for 24
hours.
The broad objective of this proposal is to identify functional neuroanatomical correlates of
changes in brain functional connectivity during smoking abstinence. The investigators will
measure changes in regional blood oxygenation levels using fMRI while adult smokers and
non-smokers lie in the scanner with their eyes closed. Smokers will be scanned when they are
abstinent from smoking for 24 hrs and shortly after smoking. Our primary hypothesis is that
smoking abstinence will alter resting state brain activity (or resting state functional
connectivity; RSFC) across widely distributed neural networks and that high-resolution fMRI
will help in resolving the exact nature of such changes. Data will be analyzed using methods
developed in our laboratory and applied to other resting state datasets. All of the
procedures used in the study are well validated and introduce only minor risk to
participants (e.g. blood draw; MRI).
changes in brain functional connectivity during smoking abstinence. The investigators will
measure changes in regional blood oxygenation levels using fMRI while adult smokers and
non-smokers lie in the scanner with their eyes closed. Smokers will be scanned when they are
abstinent from smoking for 24 hrs and shortly after smoking. Our primary hypothesis is that
smoking abstinence will alter resting state brain activity (or resting state functional
connectivity; RSFC) across widely distributed neural networks and that high-resolution fMRI
will help in resolving the exact nature of such changes. Data will be analyzed using methods
developed in our laboratory and applied to other resting state datasets. All of the
procedures used in the study are well validated and introduce only minor risk to
participants (e.g. blood draw; MRI).
Inclusion Criteria:
- Right handed
- Drug free
- No known health problems
- Currently not taking any medication
- Uninterested in quitting smoking long term
Exclusion Criteria:
- Left handed/ambidextrous
- Currently taking medication
- Interested in quitting long term
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