A Study of RO4607381 in Stable Coronary Heart Disease Patients With Recent Acute Coronary Syndrome



Status:Completed
Conditions:Peripheral Vascular Disease, Cardiology
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:45 - Any
Updated:8/3/2016
Start Date:April 2008
End Date:September 2012

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Trial Summary
Trial Overview
Inclusion Criteria

A Randomized, Double-blind, Placebo-controlled Study Assessing the Effect of RO4607381 on Cardiovascular Mortality and Morbidity in Clinically Stable Patients With a Recent Acute Coronary Syndrome

This study will evaluate the potential of RO4607381 to reduce cardiovascular morbidity and
mortality in stable coronary heart disease patients with recent Acute Coronary Syndrome
(ACS) and evaluate the long term safety profile of the drug. Eligible patients in stable
condition will be randomized to receive either RO4607381 600mg po or placebo po, daily,
together with a background of standard medication for ACS (including aspirin,
antihypertensives and statins). The anticipated time on study treatment is 2+ years, and the
target sample size is 15,600 individuals.


Inclusion Criteria:

- adult patients, >=45 years of age;

- recently hospitalized for ACS;

- clinically stable;

- receiving evidence-based medical and dietary management of dyslipidemia.

Exclusion Criteria:

- uncontrolled diabetes;

- clinically unstable;

- severe anemia;

- uncontrolled hypertension;

- concomitant treatment with any other drug raising HDL-C (eg niacin, fibrates).
We found this trial at
412
sites
Clinical Trial Facility in Philidelphia Pennsylvania
415 Curie Boulevard
Philidelphia, Pennsylvania 19104
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Philidelphia, PA
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Clinical Trial Facility in Abington Pennsylvania
Abington, Pennsylvania 19001
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Clinical Trial Facility in Aiken South Carolina
Aiken, South Carolina
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Clinical Trial Facility in Akron Ohio
Akron, Ohio
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Clinical Trial Facility in Albany New York
Albany, New York 12205
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Clinical Trial Facility in Albuquerque New Mexico
Albuquerque, New Mexico
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Clinical Trial Facility in Alexandria Louisiana
Alexandria, Louisiana 71301
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Alexandria, LA
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Clinical Trial Facility in Allentowm Pennsylvania
Allentowm, Pennsylvania 18105
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Clinical Trial Facility in Almirante Brown
Almirante Brown,
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Almirante Brown,
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Clinical Trial Facility in Alpena Michigan
Alpena, Michigan 49707
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Alpena, MI
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Clinical Trial Facility in Altanta Georgia
Altanta, Georgia
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Clinical Trial Facility in Altoona Pennsylvania
Altoona, Pennsylvania 16602
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Altoona, PA
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Clinical Trial Facility in Ames Iowa
Ames, Iowa 50010
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Ames, IA
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Clinical Trial Facility in Anaheim California
Anaheim, California 92801
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Clinical Trial Facility in Anderson Indiana
Anderson, Indiana
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Anderson, IN
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Clinical Trial Facility in Ann Arbor Michigan
Ann Arbor, Michigan 48109
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Clinical Trial Facility in Asheville North Carolina
Asheville, North Carolina
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Clinical Trial Facility in Athens Ohio
Athens, Ohio 45701
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Clinical Trial Facility in Atlanta Georgia
Atlanta, Georgia
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Clinical Trial Facility in Aurora Illinois
Aurora, Illinois 60506
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Clinical Trial Facility in Austin Texas
Austin, Texas 78744
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Austin, TX
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Clinical Trial Facility in Aventura Florida
Aventura, Florida 33108
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Clinical Trial Facility in Bakersfield California
Bakersfield, California 93301
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Clinical Trial Facility in Baltimore Maryland
Baltimore, Maryland
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Clinical Trial Facility in Bangor Maine
Bangor, Maine 04402
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Clinical Trial Facility in Bannockburn Illinois
Bannockburn, Illinois
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Clinical Trial Facility in Bartlesville Oklahoma
Bartlesville, Oklahoma 74006
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Clinical Trial Facility in Beaver Pennsylvania
Beaver, Pennsylvania 15009
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Beaver, PA
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Clinical Trial Facility in Bel Air Maryland
Bel Air, Maryland 21014
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Bel Air, MD
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Clinical Trial Facility in Bellevue Washington
Bellevue, Washington 98007
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Bellevue, WA
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Clinical Trial Facility in Bellflower California
Bellflower, California 90706
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Clinical Trial Facility in Beloit Wisconsin
Beloit, Wisconsin
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Clinical Trial Facility in Bend Oregon
Bend, Oregon
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Clinical Trial Facility in Beverly Hills California
Beverly Hills, California 90211
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Clinical Trial Facility in Biddeford Maine
Biddeford, Maine
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Clinical Trial Facility in Billerica Massachusetts
Billerica, Massachusetts 01821
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Clinical Trial Facility in Billings Montana
Billings, Montana 59101
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Clinical Trial Facility in Birmingham Alabama
Birmingham, Alabama
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Clinical Trial Facility in Bloomfield Michigan
Bloomfield, Michigan
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Clinical Trial Facility in Boise Idaho
Boise, Idaho 83712
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Clinical Trial Facility in Boston Massachusetts
Boston, Massachusetts
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Clinical Trial Facility in Boynton Beach Florida
Boynton Beach, Florida 33472
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Clinical Trial Facility in Bridgeport Connecticut
Bridgeport, Connecticut
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Clinical Trial Facility in Bridgewater New Jersey
Bridgewater, New Jersey 08807
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Clinical Trial Facility in Bristol Tennessee
Bristol, Tennessee 37620
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Clinical Trial Facility in Bronx New York
Bronx, New York
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Clinical Trial Facility in Brooklyn New York
Brooklyn, New York 11215
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Clinical Trial Facility in Bryn Mawr Pennsylvania
Bryn Mawr, Pennsylvania
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Clinical Trial Facility in Buena Park California
Buena Park, California 90620
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Clinical Trial Facility in Buffalo New York
Buffalo, New York
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Clinical Trial Facility in Burbank California
Burbank, California 91505
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Clinical Trial Facility in Burke Virginia
Burke, Virginia 22015
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Clinical Trial Facility in Burlington Wisconsin
Burlington, Wisconsin 53105
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Clinical Trial Facility in Cadillac Michigan
Cadillac, Michigan 49601
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Clinical Trial Facility in Camp Hill Pennsylvania
Camp Hill, Pennsylvania 17011
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Clinical Trial Facility in Canton Ohio
Canton, Ohio 44718
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Clinical Trial Facility in Carmichael California
Carmichael, California 95608
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Clinical Trial Facility in Cary North Carolina
Cary, North Carolina 27518
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Clinical Trial Facility in Centerville Ohio
Centerville, Ohio 45459
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Clinical Trial Facility in Chapel Hill North Carolina
Chapel Hill, North Carolina
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Clinical Trial Facility in Charleston South Carolina
Charleston, South Carolina 29412
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Clinical Trial Facility in Charlotte North Carolina
Charlotte, North Carolina 28207
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Clinical Trial Facility in Charlottesville Virginia
Charlottesville, Virginia
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Clinical Trial Facility in Chaska Minnesota
Chaska, Minnesota 55318
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Clinical Trial Facility in Chicago Illinois
Chicago, Illinois
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Clinical Trial Facility in Chipley Florida
Chipley, Florida
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Clinical Trial Facility in Cincinnati Ohio
Cincinnati, Ohio
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Clinical Trial Facility in Clarksburg West Virginia
Clarksburg, West Virginia 26301
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Clinical Trial Facility in Clearwater Florida
Clearwater, Florida 33756
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Clinical Trial Facility in Cleveland Ohio
Cleveland, Ohio
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Clinical Trial Facility in Clifton New Jersey
Clifton, New Jersey
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Clinical Trial Facility in Colonial Heights Virginia
Colonial Heights, Virginia 23834
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Clinical Trial Facility in Colorado Springs Colorado
Colorado Springs, Colorado 80910
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Clinical Trial Facility in Columbia Maryland
Columbia, Maryland 21044
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Clinical Trial Facility in Columbia Missouri
Columbia, Missouri 65201
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Clinical Trial Facility in Columbia South Carolina
Columbia, South Carolina
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Clinical Trial Facility in Columbus Georgia
Columbus, Georgia 31904
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Clinical Trial Facility in Columbus Ohio
Columbus, Ohio 43214
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Clinical Trial Facility in Concord North Carolina
Concord, North Carolina 28025
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Clinical Trial Facility in Corona California
Corona, California 92879
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Clinical Trial Facility in Costa Mesa California
Costa Mesa, California 92626
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Clinical Trial Facility in Council Bluffs Iowa
Council Bluffs, Iowa 51501
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Council Bluffs, IA
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Clinical Trial Facility in Covington Georgia
Covington, Georgia 30015
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Clinical Trial Facility in Crystal River Florida
Crystal River, Florida 34429
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Clinical Trial Facility in Dallas Texas
Dallas, Texas 75390
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Clinical Trial Facility in Danbury Connecticut
Danbury, Connecticut 06810
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Danbury, CT
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Clinical Trial Facility in Danville Virginia
Danville, Virginia 24541
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Danville, VA
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Clinical Trial Facility in Davenport Iowa
Davenport, Iowa 52803
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Davenport, IA
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Clinical Trial Facility in Daytona Beach Florida
Daytona Beach, Florida 32117
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Clinical Trial Facility in Dearborn Michigan
Dearborn, Michigan 48124
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Clinical Trial Facility in Decatur Georgia
Decatur, Georgia 30033
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Decatur, GA
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Clinical Trial Facility in Deerfield Beach Florida
Deerfield Beach, Florida 33442
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Clinical Trial Facility in Delray Florida
Delray, Florida 33445
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Delray, FL
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Clinical Trial Facility in Delray Beach Florida
Delray Beach, Florida 33406
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Clinical Trial Facility in Denver Colorado
Denver, Colorado
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Clinical Trial Facility in Detroit Michigan
Detroit, Michigan
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Clinical Trial Facility in Downington Pennsylvania
Downington, Pennsylvania 19335
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Downington, PA
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Clinical Trial Facility in Doylestown Pennsylvania
Doylestown, Pennsylvania 18901
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Clinical Trial Facility in Duluth Minnesota
Duluth, Minnesota
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Clinical Trial Facility in Durham North Carolina
Durham, North Carolina
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Clinical Trial Facility in E. Bridgewater Massachusetts
E. Bridgewater, Massachusetts 02333
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