A Study of LY2951742 in Patients With Migraine



Status:Completed
Conditions:Migraine Headaches
Therapuetic Areas:Neurology
Healthy:No
Age Range:Any
Updated:2/4/2013
Start Date:June 2012
End Date:October 2013
Contact:Arteaus Therapeutics
Email:Arteaus@Choruspharma.com

Use our guide to learn which trials are right for you!

A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study of LY2951742 in Patients With Migraine


To assess the efficacy and safety of LY2951742 in the prevention of migraine headache in
migraineurs with or without aura during 3 months of treatment.


The study is comprised of 4 trial periods:

1. Screening and washout

2. Baseline for assessment of the type, frequency and severity of headaches (4 weeks)

3. Treatment (12 weeks)

4. Follow-up (12 weeks)

Inclusion Criteria:

- Have a history of migraine as defined by the International Headache Society (IHS)
International Classification of Headache Disorders II guidelines 1.1 and 1.2
(ICHD-II, Cephalgia 2004) of at least 1 year prior to enrollment, migraine onset
prior to age 50, and a moderate frequency of migraine headaches

- Women of child-bearing potential (not surgically sterile or at least 1 year
post-menopause) must test negative for pregnancy at the time of screening based on a
serum pregnancy test and must agree to use a reliable method of birth control during
the study and for 3 months following completion of participation in the study

- Have clinical laboratory test results within normal reference ranges or, if outside
the normal range, judged not clinically significant by the Investigator

- Must not be on any migraine prevention therapy, including botulinum toxin (Botox)

- Agree not to post any personal medical data related to the study or information
related to the study on any website or social media site (for example Facebook,
Twitter, et cetera) until the trial has completed

Exclusion Criteria:

- Current enrollment in, or discontinuation within the last 30 days from, a clinical
trial involving any investigational drug or device, or concurrent enrollment in any
other type of medical research judged not to be scientifically or medically
compatible with this study

- Previous completion or withdrawal from this study or any other study investigating
LY2951742 or other therapeutic antibodies that target calcitonin gene-related peptide
(CGRP)

- History of chronic migraine or migraine subtypes including hemiplegic (sporadic or
familial) migraine, ophthalmoplegic migraine, and basilar-type migraine

- History of headache (for example, cluster headache or Medication Overuse Headache
(MOH)) other than migraine or tension type headache as defined by IHS ICHD-II within
12 months prior to randomization

- Evidence of significant active psychiatric disease including, but not limited to,
manic depressive illness, schizophrenia, generalized anxiety disorder, obsessive
compulsive disorder, personality disorders, or other serious mood, anxiety,
depression or substance use disorders

- Have a history or presence of any other medical illness that in the judgment of the
investigator, indicates a medical problem that would preclude study participation

- Women who are pregnant or nursing

- Confirmed corrected QT (QTc) interval greater than (>) 470 milliseconds (msec) for
women and > 450 for men

- Excessive alcohol, opiate or barbiturate use; history of drug abuse or dependence

- In the opinion of the investigator have no other issues that would interfere with
compliance with the study requirements and completion of evaluations required for
this study
We found this trial at
34
sites
1751
mi
from 43215
Henderson, NV
Click here to add this to my saved trials
12015 E. 46th Avenue
Denver, Colorado 80239
303-477-1880
1154
mi
from 43215
Denver, CO
Click here to add this to my saved trials
104 SE 1st Avenue
Ocala, Florida 34471
352-629-5800
746
mi
from 43215
Ocala, FL
Click here to add this to my saved trials
1065
mi
from 43215
Austin, TX
Click here to add this to my saved trials
1065
mi
from 43215
Austin, TX
Click here to add this to my saved trials
Bristol, Tennessee 37620
237
mi
from 43215
Bristol, TN
Click here to add this to my saved trials
Chattanooga, Tennessee 37421
360
mi
from 43215
Chattanooga, TN
Click here to add this to my saved trials
412
mi
from 43215
Chesterfield, MO
Click here to add this to my saved trials
Dallas, Texas 75231
905
mi
from 43215
Dallas, TX
Click here to add this to my saved trials
Encino, California 91316
1983
mi
from 43215
Encino, CA
Click here to add this to my saved trials
712
mi
from 43215
Fremont, NE
Click here to add this to my saved trials
1651
mi
from 43215
Gilbert, AZ
Click here to add this to my saved trials
Greensboro, North Carolina 27408
318
mi
from 43215
Greensboro, NC
Click here to add this to my saved trials
Henderson, Nevada 89052
1751
mi
from 43215
Henderson, NV
Click here to add this to my saved trials
Houston, Texas 77074
991
mi
from 43215
Houston, TX
Click here to add this to my saved trials
Huntington Beach, California 92647
1969
mi
from 43215
Huntington Beach, CA
Click here to add this to my saved trials
Kalamazoo, Michigan 49009
210
mi
from 43215
Kalamazoo, MI
Click here to add this to my saved trials
Los Alamitos, California 90720
1969
mi
from 43215
Los Alamitos, CA
Click here to add this to my saved trials
Maclean, Virginia 22102
319
mi
from 43215
Maclean, VA
Click here to add this to my saved trials
Maitland, Florida 32751
788
mi
from 43215
Maitland, FL
Click here to add this to my saved trials
Melbourne, Florida 32935
828
mi
from 43215
Melbourne, FL
Click here to add this to my saved trials
Newport Beach, California 92660
1967
mi
from 43215
Newport Beach, CA
Click here to add this to my saved trials
Oklahoma City, Oklahoma 73103
849
mi
from 43215
Oklahoma City, OK
Click here to add this to my saved trials
Pembroke Pines, Florida
977
mi
from 43215
Pembroke Pines, FL
Click here to add this to my saved trials
Phoenix, Arizona 85023
1658
mi
from 43215
Phoenix, AZ
Click here to add this to my saved trials
San Diego, California 92108
1948
mi
from 43215
San Diego, CA
Click here to add this to my saved trials
San Diego, California 92123
1947
mi
from 43215
San Diego, CA
Click here to add this to my saved trials
San Francisco, California
2107
mi
from 43215
San Francisco, CA
Click here to add this to my saved trials
Santa Monica, California 90404
1985
mi
from 43215
Santa Monica, CA
Click here to add this to my saved trials
Springfield, Missouri 65807
585
mi
from 43215
Springfield, MO
Click here to add this to my saved trials
Sunrise, Florida 33351
965
mi
from 43215
Sunrise, FL
Click here to add this to my saved trials
Torrance, California 90502
1980
mi
from 43215
Torrance, CA
Click here to add this to my saved trials
Watertown, Massachusetts 02472
636
mi
from 43215
Watertown, MA
Click here to add this to my saved trials
1901 S Hawthorne Rd #306
Winston-Salem, North Carolina 27103
(336) 768-8062
PMG Research of Winston-Salem PMG Research of Winston-Salem, founded in 1979, occupies a 10,000 square...
306
mi
from 43215
Winston-Salem, NC
Click here to add this to my saved trials