A Multiple-dose Study of LY3031207 in Healthy Participants
| Status: | Completed |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 9/23/2012 |
| Start Date: | June 2012 |
| End Date: | October 2012 |
| Contact: | There may be multiple sites in this clinical trial. 1-877-CTLILLY (1-877-285-4559) or |
| Phone: | 1-317-615-4559 |
A Multiple-Dose, Dose-Escalation Study to Evaluate the Safety and Tolerability of LY3031207 in Healthy Subjects
The purposes of this study are to look at safety, how well the study drug is tolerated, how
much of the study drug gets into the blood stream, and how long it takes the body to get rid
of it when given to healthy Japanese and non-Japanese participants as multiple doses. In
addition, effects of 28-day oral dosing of LY3131207 on the amount of a cholesterol-lowering
drug (simvastatin) that gets into the blood stream and how long the body takes to get rid of
it will be determined. The effects of LY3131207 after single and 28-day dosing on blood
pressure will also be studied. Information about any side effects that may occur will be
collected.
Inclusion Criteria:
- Overtly healthy individuals based on the history and physical examinations as
determined by the investigator, including first generation Japanese
- Body mass index between 17.0 and 32.0 kilograms per square meter (kg/m^2), inclusive
Exclusion Criteria:
- Have known allergies to LY3031207 or any components of the formulation, simvastatin
or related compounds (other 3-Hydroxy-3-Methyl-Glutaryl-CoA [HMG CoA] reductase
inhibitors), celecoxib, or sulfonamides. Participants with known aspirin allergy or
allergic reaction to nonsteroidal anti-inflammatory drugs (NSAIDs) should also be
excluded
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