Estimating Brain Biomechanics Using MRI
| Status: | Recruiting |
|---|---|
| Conditions: | Healthy Studies, Hospital, Neurology |
| Therapuetic Areas: | Neurology, Other |
| Healthy: | No |
| Age Range: | 18 - 50 |
| Updated: | 8/11/2018 |
| Start Date: | June 5, 2012 |
| Contact: | Jennifer N Kraszewski |
| Email: | jennifer.kraszewski@nih.gov |
| Phone: | (301) 451-1869 |
Estimation of Brain Biomechanics Using MRI
Objective: In this study we will develop and apply imaging techniques to perform the first
three-dimensional (3-D) measurements of brain biomechanics during mild head movement in
healthy human subjects. Biomechanics is the application of mechanics, or the physical
principles in action when force is applied to an object, to the anatomical structure and/or
function of organisms. Such techniques will be invaluable for building computational models
of brain biomechanics, understanding variability of brain biomechanics across individual
characteristics, such as age and sex, and determining brain sub-structures at risk for damage
when movement of the head is accelerated, such as during a traumatic event.
Study Population: Measurements will be performed on 90 healthy men and women aged 18-50.
Design: We will build upon the model pioneered by our collaborator, Dr. Philip Bayly. The
model places a human subject in a magnetic resonance (MR) scanner with one of two head
support units that allows a specific range of motion. Each head support is latched such that
it can be released by the subject, and results in either a rotation of the head of
approximately 30 degrees or a flexion-extension of the head of approximately 4 degrees.
Although both supports are weighted so that the motion is repeatable if the subject is
relaxed, the subject can easily counteract the weight. The resulting
acceleration/deceleration is small (in the range of normal activities, such as turning one's
head during swimming) and has been validated and used in other human investigations of brain
biomechanics. The subject repeats the motion multiple times during the MR scan under their
own volition and desired pace to measure motion of the head and brain.
Outcome measures: This project is a pilot study evaluating the potential of extracting
three-dimensional estimates of brain deformation, such as strain measurements, using MR
imaging. A primary outcome of this project will be a fast MR acquisition sequence for
measuring 3-D brain deformation. The sequence will be evaluated by applying the protocol to
human subjects, followed by preliminary quantification of the reproducibility and stability
of deformation measurements.
three-dimensional (3-D) measurements of brain biomechanics during mild head movement in
healthy human subjects. Biomechanics is the application of mechanics, or the physical
principles in action when force is applied to an object, to the anatomical structure and/or
function of organisms. Such techniques will be invaluable for building computational models
of brain biomechanics, understanding variability of brain biomechanics across individual
characteristics, such as age and sex, and determining brain sub-structures at risk for damage
when movement of the head is accelerated, such as during a traumatic event.
Study Population: Measurements will be performed on 90 healthy men and women aged 18-50.
Design: We will build upon the model pioneered by our collaborator, Dr. Philip Bayly. The
model places a human subject in a magnetic resonance (MR) scanner with one of two head
support units that allows a specific range of motion. Each head support is latched such that
it can be released by the subject, and results in either a rotation of the head of
approximately 30 degrees or a flexion-extension of the head of approximately 4 degrees.
Although both supports are weighted so that the motion is repeatable if the subject is
relaxed, the subject can easily counteract the weight. The resulting
acceleration/deceleration is small (in the range of normal activities, such as turning one's
head during swimming) and has been validated and used in other human investigations of brain
biomechanics. The subject repeats the motion multiple times during the MR scan under their
own volition and desired pace to measure motion of the head and brain.
Outcome measures: This project is a pilot study evaluating the potential of extracting
three-dimensional estimates of brain deformation, such as strain measurements, using MR
imaging. A primary outcome of this project will be a fast MR acquisition sequence for
measuring 3-D brain deformation. The sequence will be evaluated by applying the protocol to
human subjects, followed by preliminary quantification of the reproducibility and stability
of deformation measurements.
Objective: In this study we will develop and apply imaging techniques to perform the first
three-dimensional (3-D) measurements of brain biomechanics during mild head movement in
healthy human subjects. Biomechanics is the application of mechanics, or the physical
principles in action when force is applied to an object, to the anatomical structure and/or
function of organisms. Such techniques will be invaluable for building computational models
of brain biomechanics, understanding variability of brain biomechanics across individual
characteristics, such as age and sex, and determining brain sub-structures at risk for damage
when movement of the head is accelerated, such as during a traumatic event.
Study Population: Measurements will be performed on 90 healthy men and women aged 18-50.
Design: We will build upon the model pioneered by our collaborator, Dr. Philip Bayly. The
model places a human subject in a magnetic resonance (MR) scanner with one of two head
support units that allows a specific range of motion. Each head support is latched such that
it can be released by the subject, and results in either a rotation of the head of
approximately 30 degrees or a flexion-extension of the head of approximately 4 degrees.
Although both supports are weighted so that the motion is repeatable if the subject is
relaxed, the subject can easily counteract the weight. The resulting
acceleration/deceleration is small (in the range of normal activities, such as turning one's
head during swimming) and has been validated and used in other human investigations of brain
biomechanics. The subject repeats the motion multiple times during the MR scan under their
own volition and desired pace to measure motion of the head and brain.
Outcome measures: This project is a pilot study evaluating the potential of extracting
three-dimensional estimates of brain deformation, such as strain measurements, using MR
imaging. A primary outcome of this project will be a fast MR acquisition sequence for
measuring 3-D brain deformation. The sequence will be evaluated by applying the protocol to
human subjects, followed by preliminary quantification of the reproducibility and stability
of deformation measurements.
three-dimensional (3-D) measurements of brain biomechanics during mild head movement in
healthy human subjects. Biomechanics is the application of mechanics, or the physical
principles in action when force is applied to an object, to the anatomical structure and/or
function of organisms. Such techniques will be invaluable for building computational models
of brain biomechanics, understanding variability of brain biomechanics across individual
characteristics, such as age and sex, and determining brain sub-structures at risk for damage
when movement of the head is accelerated, such as during a traumatic event.
Study Population: Measurements will be performed on 90 healthy men and women aged 18-50.
Design: We will build upon the model pioneered by our collaborator, Dr. Philip Bayly. The
model places a human subject in a magnetic resonance (MR) scanner with one of two head
support units that allows a specific range of motion. Each head support is latched such that
it can be released by the subject, and results in either a rotation of the head of
approximately 30 degrees or a flexion-extension of the head of approximately 4 degrees.
Although both supports are weighted so that the motion is repeatable if the subject is
relaxed, the subject can easily counteract the weight. The resulting
acceleration/deceleration is small (in the range of normal activities, such as turning one's
head during swimming) and has been validated and used in other human investigations of brain
biomechanics. The subject repeats the motion multiple times during the MR scan under their
own volition and desired pace to measure motion of the head and brain.
Outcome measures: This project is a pilot study evaluating the potential of extracting
three-dimensional estimates of brain deformation, such as strain measurements, using MR
imaging. A primary outcome of this project will be a fast MR acquisition sequence for
measuring 3-D brain deformation. The sequence will be evaluated by applying the protocol to
human subjects, followed by preliminary quantification of the reproducibility and stability
of deformation measurements.
- INCLUSION CRITERIA:
- Between 18 and 50 years of age
- Able to provide written informed consent
- Able to lie flat for up to 2 hours
- Able to move head up to 220 times within 45 minutes without discomfort
- Good general health based on History and Physical (H&P) or History and Assessment
(H&A)
EXCLUSION CRITERIA:
- Contra-indications to MRI scanning without contrast based on RAD&IS department MRI
safety questionnaire
- Pregnancy
- Inner ear problems causing vertigo
- History of spinal cord injury, head injury or other musculoskeletal condition that may
result in an aversion to or difficulty with turning one s head multiple times in
succession
- Claustrophobia (no sedation is permitted under this protocol)
- Weight more than 250 lbs
- Height greater than 6'4"
We found this trial at
1
site
9000 Rockville Pike
Bethesda, Maryland 20892
Bethesda, Maryland 20892
Phone: 800-411-1222
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