The Variability of 25-hydroxyvitamin D Response From Crystalline 25-hydroxyvitamin D3
| Status: | Completed |
|---|---|
| Conditions: | Other Indications, Gastrointestinal |
| Therapuetic Areas: | Gastroenterology, Other |
| Healthy: | No |
| Age Range: | 20 - 60 |
| Updated: | 5/27/2013 |
| Start Date: | November 2012 |
| End Date: | November 2013 |
| Contact: | Susan Dowell, RN PhD |
| Email: | marydowell@creighton.edu |
| Phone: | 402-280-4647 |
The Variability of 25-hydroxyvitamin D Response From Crystalline 25-hydroxyvitamin D3 Compared to Native Vitamin D3: A Short Term Pharmacokinetic Study
The investigators hypothesize that native vitamin D will have more variability in 25(OH)D
dose response when compared to a given equipotent dose of 25-hydroxyvitamin D3. This will be
a single blind, active control, pharmacokinetic study of 625 μg 25(OH)D given orally or 2500
μg native vitamin D given orally.
Single blind, active control, pharmacokinetic study of 625 μg 25(OH)D given orally or 2500
μg native vitamin D given orally.
Inclusion Criteria:
- Ten men and women in each group,
- aged 20-60.
Exclusion Criteria:
- History of hypercalcemia,
- vitamin D supplement use > 800 IU daily,
- BMI > 30,
- gastrointestinal malabsorption (from celiac sprue, colitis, surgery, etc.), kidney
disease or liver disease,
- use of steroids in any form,
- anticonvulsants,
- antibiotics,
- acute illness, or
- vacation planned to "sunny climate"
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