The Variability of 25-hydroxyvitamin D Response From Crystalline 25-hydroxyvitamin D3



Status:Completed
Conditions:Other Indications, Gastrointestinal
Therapuetic Areas:Gastroenterology, Other
Healthy:No
Age Range:20 - 60
Updated:5/27/2013
Start Date:November 2012
End Date:November 2013
Contact:Susan Dowell, RN PhD
Email:marydowell@creighton.edu
Phone:402-280-4647

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The Variability of 25-hydroxyvitamin D Response From Crystalline 25-hydroxyvitamin D3 Compared to Native Vitamin D3: A Short Term Pharmacokinetic Study


The investigators hypothesize that native vitamin D will have more variability in 25(OH)D
dose response when compared to a given equipotent dose of 25-hydroxyvitamin D3. This will be
a single blind, active control, pharmacokinetic study of 625 μg 25(OH)D given orally or 2500
μg native vitamin D given orally.


Single blind, active control, pharmacokinetic study of 625 μg 25(OH)D given orally or 2500
μg native vitamin D given orally.

Inclusion Criteria:

- Ten men and women in each group,

- aged 20-60.

Exclusion Criteria:

- History of hypercalcemia,

- vitamin D supplement use > 800 IU daily,

- BMI > 30,

- gastrointestinal malabsorption (from celiac sprue, colitis, surgery, etc.), kidney
disease or liver disease,

- use of steroids in any form,

- anticonvulsants,

- antibiotics,

- acute illness, or

- vacation planned to "sunny climate"
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