Impulsivity, Neural Deficits and Cocaine Addiction
| Status: | Completed |
|---|---|
| Conditions: | Psychiatric, Pulmonary |
| Therapuetic Areas: | Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 11/18/2012 |
| Start Date: | April 2007 |
| End Date: | March 2012 |
| Contact: | Bryon Adinoff, MD |
| Email: | bryon.adinoff@utsouthwestern.edu |
| Phone: | 214-645-6975 |
Impulsivity, Neural Deficits, and Relapse in Cocaine Addiction
The purpose of this study is to assess neurocognitive and associated neural
regions/circuitry disruptions relevant to impulsive relapse in cocaine-addicted subjects,
and the relationship of the cognitive and neural mechanisms of impulsivity/decision-making
to relapse style.
This study is designed to explore putative differences in impulsive behaviors and decision
making in cocaine-addicted and healthy control subjects using functional magnetic resonance
imaging (fMRI), single photon emission tomography (SPECT), and neurocognitive tasks. We
predict that cocaine-addicted subjects will demonstrate neurocognitive and neural
alterations in measures of impulsivity and decision-making when compared to healthy
controls. That is, cocaine-addicted subjects will show both decreased activation and
decreased resting measures of regional cerebral blood flow (rCBF) of the brain structures
associated with impulsivity and decision-making. Furthermore, neurocognitive and neural
deficits associated with impulsivity and decision-making will be associated with each other
and with measures indicative of an impulsive relapse and altered decision making.
Inclusion Criteria:
- Cocaine-dependence (patient population) or no cocaine-dependence (control
population).
Exclusion Criteria:
- Other medical or psychiatric disorders that may effect neural functioning.
- Medications that may effect neural functioning.
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