Photo-therapy With a Topical Retinoid Versus Photo-therapy Alone for Actinic Keratoses

Evaluating safety and efficacy of the use of topical retinoid with photodynamic therapy vs
photodynamic therapy alone for the treatment of actinic keratoses.

Inclusion Criteria

- Adults aged 18-80 years old

- Subjects with AK lesions who will receive PDT

- Subjects with AK lesions in two areas other than face and scalp each with a surface
area of 10cm2 or greater and at least 3 clinically diagnosed non-hypertrophic AK
lesions in each

- Subjects in good health

- Subjects with willingness and the ability to understand and provide informed consent

Exclusion Criteria

- Subjects who are pregnant or lactating

- Subjects with a history of cutaneous photosensitivity or porphyria, hypersensitivity
to porphyrins, or photodermatosis

- Subjects with use of photosensitizing drugs within 1 week of study start

- Subjects with use of topical medications such as corticosteroids, alpha-hydroxyacids
or retinoids 2 weeks before study entry

- Subjects who received previous treatment of target AKs within 4 weeks

- Subjects who are unable to understand the protocol or give informed consent