Pilot Study of Hyperbaric Oxygen Therapy (HBOT) in Chronic Traumatic Brain Injury (TBI)/Post Concussion Syndrome (PCS) and TBI/Post-Traumatic Stress Disorder (PTSD)
| Status: | Completed |
|---|---|
| Conditions: | Hospital, Neurology, Psychiatric |
| Therapuetic Areas: | Neurology, Psychiatry / Psychology, Other |
| Healthy: | No |
| Age Range: | 18 - 45 |
| Updated: | 5/3/2014 |
| Start Date: | September 2008 |
| End Date: | May 2009 |
Hyperbaric Oxygen Therapy (HBOT) in Chronic Traumatic Brain Injury (TBI)/Post Concussion Syndrome (PCS) and TBI/Post-Traumatic Stress Disorder (PTSD) Pilot Trial
This is a pilot trial to see if one or two 40 treatment courses of low pressure hyperbaric
oxygen therapy can improve cognition and brain imaging in subjects with either chronic
mild-moderate traumatic brain injury (TBI), also known as post-concussion syndrome (PCS) or
chronic PCS with post-traumatic stress disorder (PTSD) secondary to blast injury.
oxygen therapy can improve cognition and brain imaging in subjects with either chronic
mild-moderate traumatic brain injury (TBI), also known as post-concussion syndrome (PCS) or
chronic PCS with post-traumatic stress disorder (PTSD) secondary to blast injury.
Inclusion Criteria:
- Adults, 18-45 years old
- One or more mild-moderate TBI's characterized by loss of consciousness due to blast
injury that is a minimum of one and maximum of four years old
- Absence of acute cardiac arrest or hemorrhagic shock at time of TBI.
- Absence of intracranial neurosurgery post-TBI
- Disability Rating Scale of 0-3
- Negative Addiction Severity Index (Severity score of less than 2)
- Negative urine toxicology screen for drugs of abuse
- Negative pregnancy test in females
- Otherwise good health
- Less than 90% on the Percent Back to Normal Rating Scale
Exclusion Criteria:
- Pulmonary disease that precludes HBOT
- Unstable medical conditions that are contraindicated in HBOT
- Severe confinement anxiety
- Pregnancy
- Other pre-TBI neurological diagnoses
- Pre or post TBI history of substance abuse
- Pre or post TBI history of alcoholism.
- Participation in another experimental trial with active intervention.
- High probability of inability to complete the experimental protocol.
- Previous HBOT
- History of hospitalization for past TBI, stroke, nonfebrile seizures, or any seizure
history other than seizure at the time of TBI
- Past or current history of mental retardation (baseline FSIQ < 71.
- Pre/post-TBI history of systemic illness with impact on CNS (P.I.'s decision)
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