Bipolar Disorder in Late Life

Individuals with bipolar disorder or those with a history of bipolar disorder may have
certain structural changes in their brain. The purpose of this study is to look at those
changes, as well as the assessment of risk factors for bipolar disorders, involving both
social and psychological aspects of behavior, age, education, marital relations, nutrition,
physical activity, etc., compared with persons not having bipolar disorder. These changes
in the brain will be measured by Magnetic Resonance Imaging (MRI). A blood sample for
genetic testing as we will be studying the relationship of genetics and changes in the
structure the brain as evidenced by persons having MRI hyperintensities.

Inclusion Criteria:

1. DSM-IV diagnosis of bipolar Disorder, Manic and mixed episodes.

2. 18 years of age and older, male or female, any race. Half the subjects will be above
age 50.

3. Capacity to give informed consent and follow study procedures.

Exclusion Criteria:

1. History of alcohol/drug dependence

2. Any metal or pacemaker in the body which precludes MRI

3. Pregnancy

4. Dementia or other primary psychiatric disorders including substance abuse/dependence,
anxiety disorders, schizophrenia

5. For controls, numbers one through four above as well as any history of depression or
the use of antidepressants