Effects of Fish Oil on Post Ablation Arrhythmias
| Status: | Completed |
|---|---|
| Conditions: | Atrial Fibrillation |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - 70 |
| Updated: | 4/2/2016 |
| Start Date: | November 2008 |
| End Date: | October 2010 |
| Contact: | Jacqueline J Fortino, RN /BSN |
| Email: | jfortino@umich.edu |
| Phone: | 734-615-2680 |
Effect of Omega-3 Fatty Acids on Short and Long-Term Maintenance of Sinus Rhythm After Radiofrequency Catheter Ablation for Atrial Fibrillation
To determine if peri-operative treatment with omega-3 fatty acids is associated with a
decrease in the incidence of early recurrences of atrial arrhythmias (within 30 days) and an
improvement in probability of long-term maintenance of sinus rhythm after radiofrequency
catheter ablation for Atrial Fibrillation.
decrease in the incidence of early recurrences of atrial arrhythmias (within 30 days) and an
improvement in probability of long-term maintenance of sinus rhythm after radiofrequency
catheter ablation for Atrial Fibrillation.
AF is the most prevalent arrhythmia, affecting >2 million Americans. Antiarrhythmic drug
therapy often is ineffective to eliminate recurrent episodes of AF. In recent years
radiofrequency catheter ablation has emerged as a highly effective treatment strategy in
patients with paroxysmal and chronic AF.6, 7 However, AF may recur within days to weeks
after a successful ablation procedure in up to 50% of the patients, probably because of an
inflammatory response to thermal injury caused by radiofrequency energy application. These
early recurrences of AF after ablation do not necessarily predict long-term clinical outcome
and 30-50% of patients who develop early recurrences ultimately remain in sinus rhythm
without the need for additional ablation.8 However, early recurrences of AF may be
associated with significant morbidity due to troubling symptoms of rapid ventricular rates,
multiple hospital visits and cardioversions, need for antiarrhythmic drug therapy and
prolongation in duration of anticoagulant therapy. It is also possible that if early
recurrences of AF after ablation can be avoided, the probability of remaining in sinus
rhythm during long-term follow-up may be higher, as maintenance of sinus rhythm early-on may
facilitate reverse left atrial remodeling. A similar phenomenon may occur in post-operative
AF, that develops in ~30% of patients who undergo cardiac surgery. Post-operative AF is
often transient and usually resolves within 3 months after the surgery. Perioperative
treatment with omega-3 fatty acids has been reported to decrease the incidence of
postoperative AF after coronary artery by-pass surgery.4 Because the pathogenetic factors
that play a role in postoperative AF and early recurrences of AF after radiofrequency
catheter ablation may be similar, it is plausible that treatment with omega-3 fatty acids
before and after ablation will be associated with a reduction in the incidence of early
recurrences of AF.
therapy often is ineffective to eliminate recurrent episodes of AF. In recent years
radiofrequency catheter ablation has emerged as a highly effective treatment strategy in
patients with paroxysmal and chronic AF.6, 7 However, AF may recur within days to weeks
after a successful ablation procedure in up to 50% of the patients, probably because of an
inflammatory response to thermal injury caused by radiofrequency energy application. These
early recurrences of AF after ablation do not necessarily predict long-term clinical outcome
and 30-50% of patients who develop early recurrences ultimately remain in sinus rhythm
without the need for additional ablation.8 However, early recurrences of AF may be
associated with significant morbidity due to troubling symptoms of rapid ventricular rates,
multiple hospital visits and cardioversions, need for antiarrhythmic drug therapy and
prolongation in duration of anticoagulant therapy. It is also possible that if early
recurrences of AF after ablation can be avoided, the probability of remaining in sinus
rhythm during long-term follow-up may be higher, as maintenance of sinus rhythm early-on may
facilitate reverse left atrial remodeling. A similar phenomenon may occur in post-operative
AF, that develops in ~30% of patients who undergo cardiac surgery. Post-operative AF is
often transient and usually resolves within 3 months after the surgery. Perioperative
treatment with omega-3 fatty acids has been reported to decrease the incidence of
postoperative AF after coronary artery by-pass surgery.4 Because the pathogenetic factors
that play a role in postoperative AF and early recurrences of AF after radiofrequency
catheter ablation may be similar, it is plausible that treatment with omega-3 fatty acids
before and after ablation will be associated with a reduction in the incidence of early
recurrences of AF.
Inclusion Criteria:
- Age > 18 years and < 70 years old
- Left atrial size <55 mm
Exclusion Criteria:
- Inability or unwillingness to provide informed consent
- Current therapy with omega-3 fatty acids
- Current therapy with a statin
- Active liver disease
- Significant comorbidity such as end-stage renal disease or cirrhosis
- Valvular prosthesis
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