Real Time Microscopic Imaging During Robot Assisted Prostate Cancer Surgery
| Status: | Completed |
|---|---|
| Conditions: | Prostate Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 5/3/2014 |
| Start Date: | November 2008 |
| End Date: | August 2009 |
| Contact: | Randy Fagin, MD |
| Email: | randy.fagin@gmail.com |
| Phone: | 512-657-6548 |
In Vivo Confocal Endomicroscopy During da Vinci Robot Assisted Prostatectomy: Feasibility Study
The study involves use of a device called an endomicroscope to obtain high resolution images
of microscopic structures during robot-assisted prostate cancer surgery. This feasibility
study is largely descriptive, and will use endomicroscopy to document the cellular and
architectural appearance of tissue during minimally invasive prostate surgery for later
comparison with features seen upon conventional histopathological examination of biopsies or
resection specimens.
of microscopic structures during robot-assisted prostate cancer surgery. This feasibility
study is largely descriptive, and will use endomicroscopy to document the cellular and
architectural appearance of tissue during minimally invasive prostate surgery for later
comparison with features seen upon conventional histopathological examination of biopsies or
resection specimens.
Prostate surgery requires meticulous dissection around nerves and associated structures such
as the bladder, seminal vesicles and vas deferens. Nerve damage during prostatectomy can
result in undesirable outcomes such as impotence and urinary incontinence. Robot assisted
minimally invasive prostatectomy offers enhanced visualisation of the surgical field.
Superior clinical outcomes in terms of length of hospital stay, blood loss, and oncologic
margins compared with open surgery are reported. Confocal endomicroscopy provides high
resolution subsurface cellular imaging in real time and is already in clinical use in
gastroenterology and under investigation in other surgical applications. A potential role
exists for confocal endomicroscopy to enhance microscopic nerve identification
intra-operatively and guide surgical decision making during robot-assisted prostatectomy.
as the bladder, seminal vesicles and vas deferens. Nerve damage during prostatectomy can
result in undesirable outcomes such as impotence and urinary incontinence. Robot assisted
minimally invasive prostatectomy offers enhanced visualisation of the surgical field.
Superior clinical outcomes in terms of length of hospital stay, blood loss, and oncologic
margins compared with open surgery are reported. Confocal endomicroscopy provides high
resolution subsurface cellular imaging in real time and is already in clinical use in
gastroenterology and under investigation in other surgical applications. A potential role
exists for confocal endomicroscopy to enhance microscopic nerve identification
intra-operatively and guide surgical decision making during robot-assisted prostatectomy.
Inclusion Criteria:
- Males diagnosed with prostate cancer and undergoing da Vinci radical prostatectomy
Exclusion Criteria:
- Patients under 18 years of age
- Patients with allergy or prior adverse reaction to Fluorescein Sodium
- Patients unable to give informed consent
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