Effect of KB003 in Subjects With Asthma Inadequately Controlled by Corticosteroids

Key Inclusion Criteria:

- A diagnosis of asthma established for at least 2 years

- Symptomatic asthma as defined by the Juniper Asthma Control Questionnaire

- Symptomatic asthma despite stable treatment with inhaled corticosteroids fluticasone
or budesonide, or other corticosteroids, for at least 12 weeks

- Currently receiving inhaled long-acting beta agonist (LABA) or previously documented
LABA intolerability or lack of responsiveness

- At least 2 exacerbations (no more than 6) in the previous 12 months that required
systemic corticosteroids or at least a doubling of daily oral dose

Key Exclusion Criteria:

- Acute asthma worsening (requiring emergency room visit, hospitalization, urgent care,
physician visit, or change in asthma medications) or lower respiratory tract
infection requiring the use of antibiotics, within 4 weeks prior to Screening Visit.

- History of life-threatening asthma with admission to the intensive care unit
requiring the use of mechanical ventilation within the past 12 months

- Use of any immunosuppressive or immunomodulatory agents within 12 weeks or an
investigational agent within 4 weeks prior to Screening Visit

- History of any cardiovascular, neurological, hepatic, or renal condition

- History of smoking within the past 12 months