Trial of 2% Chlorhexidine Bathing on Nosocomial Infections in the Surgical Intensive Care Unit
| Status: | Completed |
|---|---|
| Conditions: | Pneumonia, Infectious Disease, Hospital |
| Therapuetic Areas: | Immunology / Infectious Diseases, Pulmonary / Respiratory Diseases, Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/29/2018 |
| Start Date: | July 2012 |
| End Date: | September 2014 |
Randomized Controlled Trial of 2% Chlorhexidine Bathing on Nosocomial Infections in the Surgical Intensive Care Unit
This prospective, randomized, controlled trial will compare the incidence of nosocomial
infections (composite of primary bloodstream infections, catheter-associated urinary tract
infections, ventilator-associated pneumonia, and surgical site infections) that occur in
intensive care unit (ICU) patients bathed with 2% chlorhexidine solution versus patients who
receive standard bathing (soap and water or non-medicated cloths).
infections (composite of primary bloodstream infections, catheter-associated urinary tract
infections, ventilator-associated pneumonia, and surgical site infections) that occur in
intensive care unit (ICU) patients bathed with 2% chlorhexidine solution versus patients who
receive standard bathing (soap and water or non-medicated cloths).
Upon study enrollment, patients will be randomized to one of two study arms. Patients in
study arm one will receive standard bathing (soap and water or non-medicated cloth) daily.
Patients in study arm two will receive a 2% chlorhexidine bath on study day 1 and every 48
hours and a standard bath (soap and water or non-medicated cloths) on study day 2 and every
48 hours. Patients will be followed until ICU day 28 or discharged from the surgical ICU.
Hypothesis: Compared to standard daily bathing, chlorhexidine-based bathing on ICU admission
and every 48 hours will decrease the incidence of nosocomial infections.
study arm one will receive standard bathing (soap and water or non-medicated cloth) daily.
Patients in study arm two will receive a 2% chlorhexidine bath on study day 1 and every 48
hours and a standard bath (soap and water or non-medicated cloths) on study day 2 and every
48 hours. Patients will be followed until ICU day 28 or discharged from the surgical ICU.
Hypothesis: Compared to standard daily bathing, chlorhexidine-based bathing on ICU admission
and every 48 hours will decrease the incidence of nosocomial infections.
Inclusion Criteria:
- Admission to the surgical intensive care unit at The Methodist Hospital (Houston, TX)
- Anticipated surgical intensive care unit length of stay of 48 hours or more
Exclusion Criteria:
- Pregnancy
- Age less than 18 years old
- Braden score of less than 9 upon admission to the surgical intensive care unit
- Known allergy to chlorhexidine gluconate
- Active skin irritation upon admission to the surgical intensive care unit
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