Effects of Eszopiclone on Sleep and Memory in Schizophrenia
| Status: | Completed |
|---|---|
| Conditions: | Schizophrenia |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - 45 |
| Updated: | 4/2/2016 |
| Start Date: | July 2012 |
| End Date: | June 2015 |
| Contact: | Tessa Vuper, BS |
| Email: | tcvuper@nmr.mgh.harvard.edu |
| Phone: | 617-726-1908 |
Sleep-dependent Memory Processing in Schizophrenia
The investigators will test the hypothesis that the sleep medication, eszopiclone, can
normalize brain activity during sleep and improve memory in patients with schizophrenia. The
investigators will do this by comparing sleep and performance in participants taking
eszopiclone to participants taking placebo. The investigators will study healthy subjects
and patients with schizophrenia taking atypical antipsychotic medications.
normalize brain activity during sleep and improve memory in patients with schizophrenia. The
investigators will do this by comparing sleep and performance in participants taking
eszopiclone to participants taking placebo. The investigators will study healthy subjects
and patients with schizophrenia taking atypical antipsychotic medications.
Inclusion Criteria:
- clinically stable outpatients with schizophrenia,
- proficient in English,
- able to give informed consent,
- maintained on a stable dose of atypical antipsychotic medications for at least 6
weeks prior to enrollment.
- healthy Control participants matched as a group to the patients for age, sex, and
parental socioeconomic status.
Exclusion Criteria:
- Substance abuse or dependence within the past six months;
- other chronic medical conditions that affect sleep; (- pregnancy/breast feeding;
- hepatic impairment;
- treatment with inhibitors or inducers of CYP 3A4 or 2E1 enzymes (which metabolize
eszopiclone);
- a history of head injury resulting in prolonged loss of consciousness or other
neurological sequelae; (- mental retardation; (- a diagnosed sleep disorder other
than insomnia,
- neurological disorder; sleep disorder, other than insomnia, identified in a clinical
sleep evaluation.
Patients on conventional agents, benzodiazepines, or other sleep agents will be excluded.
Potential controls will be excluded for a personal history of mental illness, a family
history of schizophrenia spectrum disorder or psychosis, and treatment with medications
known to affect sleep or cognition.
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