Intestinal Permeability in Response to Treatment in Eosinophilic Esophagitis Patients

Eosinophilic esophagitis is an allergy mediated disease in which antigens exposed to the
gastrointestinal tract trigger a combined immediate hypersensitivity.

The investigators anticipate that patients with active eosinophilic esophagitis will have
increased intestinal permeability on urine collection of sugars. The investigators are not
sure whether these findings will be found in patients who have been successfully treated
with topical esophageal steroids. Improvement in intestinal permeability would be perceived
as indicating that esophageal disease drives the intestinal permeability. Lack of
improvement would indicate that eosinophilic esophagitis is a more systemic disease in which
increased small bowel permeability is a marker or perhaps important driver of the disease.

Inclusion Criteria:

- Subjects between the ages of 18 and 80 with Eosinophilic Esophagitis diagnosed by
compatible symptoms, endoscopic findings, histology and lack of response to proton
pump inhibitors or negative pH study.

Exclusion:

- Vulnerable populations, such as those with diminished mental acuity, will be
excluded.

- Patients allergic to Lactulose

- Women who are pregnant or lactating.