Cancer Biology of Retinoblastoma
| Status: | Recruiting |
|---|---|
| Conditions: | Brain Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | Any - 5 |
| Updated: | 4/2/2016 |
| Start Date: | July 2012 |
| End Date: | December 2017 |
Many children with the childhood cancer, Retinoblastoma, have surgery to remove the tumor
and sometimes the entire eye. The purpose of this study is to collect the extra tissue from
patients who undergo tumor removal for laboratory experiments that will help us understand
not only what occurs in retinoblastoma cells but also how cells normally function. Some of
these studies will include an evaluation of how cells control the way that genes are
expressed, how cells "know" to become retinal cells, how cells remain retinal cells, how
cells lose their identity as retinal cells, what changes make retinoblastoma cells different
from normal retinal cells, and what changes make some retinoblastomas worse than others.
and sometimes the entire eye. The purpose of this study is to collect the extra tissue from
patients who undergo tumor removal for laboratory experiments that will help us understand
not only what occurs in retinoblastoma cells but also how cells normally function. Some of
these studies will include an evaluation of how cells control the way that genes are
expressed, how cells "know" to become retinal cells, how cells remain retinal cells, how
cells lose their identity as retinal cells, what changes make retinoblastoma cells different
from normal retinal cells, and what changes make some retinoblastomas worse than others.
Inclusion Criteria:
- Patient must have retinoblastoma
- Patient must be receiving biopsy, partial surgical excision of the tumor, complete
excision of the tumor, or enucleation of the eye as part of their standard care.
- Parental consent
Exclusion Criteria:
- Diagnosis other than Retinoblastoma
- No surgical sampling of tumor is planned as part of standard care
- Parental preference to not participate.
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