Safety and Efficacy of Linaclotide in Patients With Chronic Constipation and Prominent Abdominal Bloating

Inclusion Criteria:

- Patient has completed a colonoscopy according to the American Gastroenterological
Association criteria with no clinically significant findings

- Patient has successfully completed protocol procedures (with no clinically
significant findings)

- Patient meets protocol criteria for Chronic Constipation(CC): < 3 bowel movements per
week and reports one or more of the following symptoms for at least 12 weeks:

1. Straining during more than 25% of BMs

2. Lumpy or hard stools during more than 25% of BMs

3. Sensation of incomplete evacuation during more than 25% of BMs

- Patient demonstrates continued chronic constipation and bloating through Pretreatment
Period

- Patient is compliant with Interactive voice response System (IVRS)

Exclusion Criteria:

- Patient has a history of loose or watery stools

- Patient has symptoms of or been diagnosed with Irritable Bowel Syndrome (IBS)

- Patient has a structural abnormality of the gastrointestinal (GI) tract or a disease
or condition that can affect GI motility

- Patient has any protocol-excluded or clinically significant medical or surgical
history that would limit the patient's ability to complete or participate in this
clinical trial or could confound the study assessments