Comparative Effectiveness of Treatment Strategies for Primary Open-Angle Glaucoma

The primary objectives of the study are:

1. To compare the proportion of patients who achieve a successful response to treatment
(reduction in IOP of >15%) between patients treated with laser surgery (including argon
laser trabeculectomy, and selective laser trabeculoplasty) with patients receiving
additional medications, at 1-year post-treatment initiation.

2. To compare the proportion of patients who achieve a successful response to treatment
(reduction in IOP of >15%) between patients treated with other procedures (including
incisional surgery, drainage device procedures, and other glaucoma procedures) with
patients receiving additional medications, at 1-year-post-treatment initiation.

The study is a prospective, observational cohort study and will not provide or recommend any
treatment. Patients who have failed initial medical therapy with two glaucoma medications
will be identified and enrolled at the time of scheduling of a laser surgery procedure or
other procedure such as incisional surgery or drainage device, or initiation of an
additional course of therapy with medication as determined by their physician. This
inception cohort of new initiators of laser surgical treatment, other procedures, or
additional medical therapy will be followed for 12 months. All decisions regarding treatment
are solely at the discretion of the physician in accordance with their usual practice.
Enrollment is expected to begin in February 2011 and continue through 12 months of follow-up
after enrollment targets have been reached.