A Study in Participants With Moderate to Severe Psoriasis (UNCOVER-3)

Inclusion Criteria:

- Presents with chronic plaque psoriasis based on a confirmed diagnosis of chronic
psoriasis for at least 6 months prior to randomization

- At least 10% Body Surface Area (BSA) of Psoriasis at screening and at randomization

- sPGA score of at least 3 and PASI score of at least 12 at screening and at
randomization

- Candidate for phototherapy and/or systemic therapy

- Men must agree to use a reliable method of birth control or remain abstinent during
the study

- Women must agree to use reliable birth control or remain abstinent during the study
and for at least 12 weeks after stopping treatment

Exclusion Criteria:

- Pustular, erythrodermic, and/or guttate forms of psoriasis

- History of drug-induced psoriasis

- Prior use of etanercept

- Clinically significant flare of psoriasis during the 12 weeks prior to randomization

- Concurrent or recent use of any biologic agent

- Received non-biologic systemic psoriasis therapy or phototherapy (including psoralens
and ultraviolet A [PUVA], ultraviolet B [UVB]) within the previous 4 weeks; or had
topical psoriasis treatment within the previous 2 weeks prior to randomization

- Cannot avoid excessive sun exposure or use of tanning booths for at least 4 weeks
prior to randomization and during the study

- Have participated in any study with interleukin 17 (IL-17) antagonists, including
ixekizumab

- Serious disorder or illness other than plaque psoriasis

- Serious infection within the last 3 months

- Breastfeeding or nursing (lactating) women