A Study of IMC-TR1 in Participants With Advanced Solid Tumors

This is the first-in-human Phase 1 study of IMC-TR1.

Inclusion Criteria:

- Part A and Part B: Participants must be appropriate candidates for experimental
therapy, with a solid tumor that has failed standard therapy or for which no standard
therapy is available, and evidence of progressive disease

- Part A only: Participants must have histological or cytological evidence of a
solid tumor which is advanced and/or metastatic

- Part B only: Participants who have failed first-line therapy/standard of care and
have histological or cytological evidence of a cancer type for which evidence of
activity was observed during Part A or for which preclinical evidence of
potential activity has been observed

- Have the presence of measurable or nonmeasurable disease as defined by the Response
Evaluation Criteria in Solid Tumors, Version 1.1 (RECIST 1.1)

- Part A only: Participants may have measurable or nonmeasurable disease

- Part B: Participants must have measurable disease

- Have adequate organ function including: Hematologic, Hepatic, Albumin, Coagulation and
Renal function

- Have a performance status of ≤ 1 on the Eastern Cooperative Oncology Group (ECOG)
scale

- Have discontinued previous treatments for cancer and recovered from the acute effects
of therapy

- Males and females with reproductive potential must agree to use medically approved
contraceptive precautions during the study and for 3 months following the last dose of
study drug

- Females with child bearing potential must have had a negative serum pregnancy test and
must not be breastfeeding

- Have an estimated life expectancy that is > 3 months

Exclusion Criteria:

- Have clinically significant cardiac disease, including:

- Myocardial infarction within 6 months prior to study entry, unstable angina
pectoris, congestive heart failure, or uncontrolled hypertension

- Major electrocardiogram (ECG) abnormalities

- Major abnormalities documented by echocardiography with Doppler

- Have known predisposing conditions that are consistent with development of
aneurysms of the ascending aorta or aortic stress

- Have Corrected QT Interval (QTc interval) of > 500 msec on screening ECG

- Have other known serious pre-existing medical conditions

- Have received prior investigational therapy targeting Transforming growth factor beta
(TGFβ) or its receptors

- Have a known sensitivity to monoclonal antibodies or other therapeutic proteins, to
agents of similar biologic composition as IMC-TR1

- Have a high risk of gastrointestinal bleeding, active inflammatory bowel disease, or
chronic steroid use

- Are currently using or has received a systemic thrombolytic agent within 28 days prior
to enrollment

- Are receiving:

- full-dose warfarin

- intravenous heparin or low-molecular-weight heparin

- chronic daily treatment with aspirin at a dose greater than 325 mg per day or
nonsteroidal anti-inflammatory medications known to inhibit platelet function

- Have evidence of retinal disease or are a monocular participant

- Have received a solid organ transplant, bone marrow transplant or stem cell transplant

- Have symptomatic central nervous system (CNS) malignancy or untreated metastasis

- Have acute or chronic leukemia

- Have a known active fungal, bacterial, and/or viral infection including human
immunodeficiency virus or viral hepatitis requiring treatment

- Has a positive fecal occult blood test within 14 days prior to enrollment